Synthesis of Enol Ethers and Enamines by Pd-Catalyzed Tosylhydrazide-Promoted Cross-Coupling Reactions

被引：91

作者：

Barluenga, Jose ^{[1
]}

Escribano, Maria ^{[1
]}

Moriel, Patricia ^{[1
]}

Aznar, Fernando ^{[1
]}

Valdes, Carlos ^{[1
]}

机构：

[1] Univ Oviedo, Inst Univ Quim Organomet Enrique Moles, E-33006 Oviedo, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2009年 / 15卷 / 48期

关键词：

cross-coupling; enamines; enol ethers; hydrazones; palladium; CARBENE INSERTION; ALPHA-ARYLATION; BOND FORMATION; ARYL BROMIDES; VINYL HALIDES; PALLADIUM; ALDEHYDES; CLEAVAGE;

D O I：

10.1002/chem.200902718

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

"Chemical Equation Presented" α-Substitution is fine: α-Alkoxycarbonyl and α-aminocarbonyl compounds are good substrates for the recently developed tosylhydrazide-promoted Pd-catalyzed cross-coupling of carbonyls with aryl halides. The reac-tion gives rise to enol ethers and enamines, respectively, which are useful synthetic intermediates in heterocyclic synthesis. Otherwise, they can be hydrolyzed to give α,α- disubstituted aldehydes. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：13291 / 13294

页数：4