Interferon-α is effective for CD4+, CCR4-mycosis fungoides

被引：5

作者：

Fujimura, Taku ^{[1
]}

Okuyama, Ryuhei ^{[1
]}

Watabe, Akiko ^{[1
]}

Hashimoto, Akira ^{[1
]}

Tagami, Hachiro ^{[1
]}

Aiba, Setsuya ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Dermatol, Aoba Ku, Sendai, Miyagi 9808574, Japan

来源：

INTERNATIONAL JOURNAL OF DERMATOLOGY | 2007年 / 46卷 / 04期

关键词：

D O I：

10.1111/j.1365-4632.2007.03221.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Mycosis fungoides (MF), a cutaneous T-cell lymphoma, is usually characterized by cell features of T-helper-2 (Th2) lymphocytes. MF has recently been reported to show increased CCR4 expression, a chemokine receptor specifically expressed in Th2. Previously, we have reported the effectiveness of interferon-gamma (IFN-gamma) for the treatment of CCR4+ MF. In this report, we describe two cases of CD4+, CCR4- MF successfully treated with IFN-alpha, but not IFN-gamma. Although MF usually displays a Th2 profile, the tumor cells in our two cases did not express CCR4. Our cases suggest the effectiveness of IFN-alpha, but not IFN-gamma, for CCR4- MF.

引用

页码：435 / 438

页数：4

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