Interferon-α is effective for CD4+, CCR4-mycosis fungoides

被引：5
|
作者：
Fujimura, Taku [1 ]
Okuyama, Ryuhei [1 ]
Watabe, Akiko [1 ]
Hashimoto, Akira [1 ]
Tagami, Hachiro [1 ]
Aiba, Setsuya [1 ]
机构：
[1] Tohoku Univ, Grad Sch Med, Dept Dermatol, Aoba Ku, Sendai, Miyagi 9808574, Japan
来源：
INTERNATIONAL JOURNAL OF DERMATOLOGY | 2007年 / 46卷 / 04期
关键词：
D O I：
10.1111/j.1365-4632.2007.03221.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Mycosis fungoides (MF), a cutaneous T-cell lymphoma, is usually characterized by cell features of T-helper-2 (Th2) lymphocytes. MF has recently been reported to show increased CCR4 expression, a chemokine receptor specifically expressed in Th2. Previously, we have reported the effectiveness of interferon-gamma (IFN-gamma) for the treatment of CCR4+ MF. In this report, we describe two cases of CD4+, CCR4- MF successfully treated with IFN-alpha, but not IFN-gamma. Although MF usually displays a Th2 profile, the tumor cells in our two cases did not express CCR4. Our cases suggest the effectiveness of IFN-alpha, but not IFN-gamma, for CCR4- MF.
引用
收藏
页码：435 / 438
页数：4
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