Microwave-mediated palladium-catalyzed asymmetric allylic alkylation; an example of highly selective fast chemistry

被引：24

作者：

Kaiser, NFK

Bremberg, U

Larhed, M

Moberg, C ^{[1
]}

Hallberg, A

机构：

[1] Royal Inst Technol, Dept Chem Organ Chem, SE-10044 Stockholm, Sweden

[2] Uppsala Univ, Uppsala Biomed Ctr, Dept Organ Pharmaceut Chem, SE-75123 Uppsala, Sweden

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2000年 / 603卷 / 01期

基金：

瑞典研究理事会;

关键词：

allylic alkylation; enantioselectivity; fast chemistry; microwave chemistry; palladium-catalysis;

D O I：

10.1016/S0022-328X(00)00023-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Highly enantioselective palladium-catalyzed microwave-mediated fast chemistry has been performed on dimethyl malonate alkylation of(rac)-1,3-diphenylallyl-1-acetate (1). Utilizing the recently developed palladium-phosphineoxazoline catalytic system, with general stability at elevated temperatures (less than or equal to 145 degrees C), quantitative yields of greater than or equal to 97% and ee values of up to >99% were obtained after very short irradiation times (15-300 s, TOF up to 7000 h(-1)). (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：2 / 5

页数：4

共 24 条

[1] PALLADIUM-CATALYZED ASYMMETRIC ALLYLIC SUBSTITUTION - A LIGAND DESIGN INCORPORATING STERIC AND ELECTRONIC EFFECTS [J].