Gold-coated fiber Bragg gratings (FBGs) are nowadays a mature technology for lab-on-fiber sensing based on surface plasmon resonance (SPR) excitation. Tilted FBGs bring valuable assets such as easy light injection, remote operation in very small volumes of analytes and immunity to temperature fluctuations. Different gold configurations have been reported to date. without considering their relative performances in terms of biochemical sensing. In this work, we experimentally study the impact of the gold coating on the cladding mode distribution in the tilted FBG amplitude spectrum and subsequently on its sensitivity to cytokeratins used as biomarkers for cancer diagnosis. Some relevant configurations of gold coatings are produced and tested. relying on both the sputtering and electroless plating (ELP) processes. The obtained results confirm that the coating thickness and its roughness drive the biosensing performances. The experimental limit of detection for cytokeratins 17 sensing reaches 14 fM for the most sensitive configurations. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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City Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
City Univ London, City Grad Sch, London EC1V 0HB, England
Harbin Inst Technol, Sch Mechatron Engn, Harbin 150001, Peoples R ChinaCity Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
Cao, Jie
;
Tu, Minh Hiue
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City Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
City Univ London, City Grad Sch, London EC1V 0HB, EnglandCity Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
Tu, Minh Hiue
;
Sun, Tong
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City Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
City Univ London, City Grad Sch, London EC1V 0HB, EnglandCity Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
Sun, Tong
;
Grattan, Kenneth T. V.
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City Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
City Univ London, City Grad Sch, London EC1V 0HB, EnglandCity Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
机构:
City Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
City Univ London, City Grad Sch, London EC1V 0HB, England
Harbin Inst Technol, Sch Mechatron Engn, Harbin 150001, Peoples R ChinaCity Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
Cao, Jie
;
Tu, Minh Hiue
论文数: 0引用数: 0
h-index: 0
机构:
City Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
City Univ London, City Grad Sch, London EC1V 0HB, EnglandCity Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
Tu, Minh Hiue
;
Sun, Tong
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机构:
City Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
City Univ London, City Grad Sch, London EC1V 0HB, EnglandCity Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
Sun, Tong
;
Grattan, Kenneth T. V.
论文数: 0引用数: 0
h-index: 0
机构:
City Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
City Univ London, City Grad Sch, London EC1V 0HB, EnglandCity Univ London, Sch Engn & Math Sci, London EC1V 0HB, England