An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila

被引：36

作者：

Shi, Dan ^{[1
]}

Han, TianShu ^{[1
]}

Chu, Xia ^{[1
]}

Lu, Huimin ^{[1
]}

Yang, Xue ^{[1
]}

Zi, TianQi ^{[1
]}

Zhao, YanHe ^{[1
]}

Wang, XinYue ^{[1
]}

Liu, ZhiPeng ^{[1
]}

Ruan, JingQi ^{[1
]}

Liu, Xin ^{[1
]}

Ning, Hua ^{[1
]}

Wang, MaoQing ^{[1
]}

Tian, Zhen ^{[1
]}

Wei, Wei ^{[1
]}

Sun, Yue ^{[1
]}

Li, YinLing ^{[1
]}

Guo, Rui ^{[1
]}

Wang, Yu ^{[1
]}

Ling, Fan ^{[1
]}

Guan, Yue ^{[1
]}

Shen, Da ^{[2
]}

Niu, YuCun ^{[1
]}

Li, Ying ^{[1
]}

Sun, ChangHao ^{[1
]}

机构：

[1] Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Natl Key Discipline Lab, Harbin, Peoples R China

[2] Tsinghua Univ, Sch Med, Gene Regulatory Lab, Beijing 100084, Peoples R China

来源：

CELL METABOLISM | 2021年 / 33卷 / 03期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

OXIDATIVE STRESS; C; ELEGANS; BETA-HYDROXYBUTYRATE; PPAR-GAMMA; LONGEVITY; ACID; INFLAMMATION; METABOLISM; ACTIVATION; HEALTH;

D O I：

10.1016/j.cmet.2020.12.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The health effect of dietary fat has been one of the most vexing issues in the field of nutrition. Few animal studies have examined the impact of high-fat diets on lifespan by controlling energy intake. In this study, we found that compared to a normal diet, an isocaloric moderately high-fat diet (IHF) significantly prolonged lifespan by decreasing the profiles of free fatty acids (FFAs) in serum and multiple tissues via downregulating FFA anabolism and upregulating catabolism pathways in rats and flies. Proteomics analysis in rats identified PPRC1 as a key protein that was significantly upregulated by nearly 2-fold by IHF, and among the FFAs, only palmitic acid (PA) was robustly and negatively associated with the expression of PPRC1. Using PPRC1 transgenic RNAi/overexpression flies and in vitro experiments, we demonstrated that IHF significantly reduced PA, which could upregulate PPRC1 through PPARG, resulting in improvements in oxidative stress and inflammation and prolonging the lifespan.

引用

页码：581 / +

页数：26

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