Biopolyphenolics as antioxidants: Studies under an Indo-Italian CSIR-CNR project

被引：14

作者：

Foti, MC

Sharma, SK

Shakya, G

Prasad, AK

Nicolosi, G

Bovicelli, P

Ghosh, B

Raj, HG

Rastogi, RC

Parmar, VS

机构：

[1] CNR, Sez Catania, Ist Chim Biomol, I-95028 Valverde, CT, Italy

[2] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 110007, India

[3] Univ Roma La Sapienza, CNR, Sez Roma, Ist Chim Biomol, I-00185 Rome, Italy

[4] Inst Genom & Integrat Biol, Mol Immunol & Immunogenet Lab, Delhi 110007, India

[5] Univ Delhi, Vallabhbhai Patel Chest Inst, Dept Biochem, Delhi 110007, India

来源：

PURE AND APPLIED CHEMISTRY | 2005年 / 77卷 / 01期

关键词：

D O I：

10.1351/pac200577010091

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A wide variety of polyphenolic compounds (i.e., 4-methylcoumarins, xanthones, pyrazoles, and pyrazolylacrylonitriles) have been examined for their antioxidant effect on NADPH-catalyzed liver-microsomal lipid peroxidation with a view to establishing their structure-activity relationship. Dihydroxy-/diacetoxy-4-methylcoumarin derivatives have been shown to be radical scavengers. The effect of nine different xanthones has been examined on the modulation of cytokine-induced expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells. 1,4-Dihydroxyxanthone showed enhanced antioxidant activity as well as ICAM-1 inhibitory activity.

引用

页码：91 / 101

页数：11

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