Effect of alcoholic intoxication on water content and activity of Na,K-ATPase and Ca-ATPase in rat brain

被引：7
|
作者：
Zamai, TN [1 ]
Titova, NM [1 ]
Zamai, AS [1 ]
Usol'tseva, OS [1 ]
Yulenkova, OV [1 ]
Shumkova, AA [1 ]
机构：
[1] Krasnoyarsk State Univ, Dept Human & Anim Biochem & Physiol, Krasnoyarsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 134卷 / 06期
关键词：
alcohol intoxication; brain; Na; K-ATPase; Ca-ATPase; malonic dialdehyde;
D O I：
10.1023/A:1022948709336
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of 2-week alcohol intoxication on water exchange and activity of Na,K-ATPase and Ca-ATPase in rat brain. Alcohol intoxication increased water content in the brain due to cell hyperhydration. It is assumed that hyperhydration results from increased Na+ content in cells due to inhibition Na,K-ATPase activity, which in turn is caused by activation of lipid peroxidation under the effect of ethanol. A possible mechanism of Na,K-ATPase inhibition.
引用
收藏
页码：541 / 543
页数：3
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