Design, synthesis and antibacterial activity of novel andrographolide derivatives

被引：45
作者：
Wang, Zhongli
Yu, Pei [1 ]
Zhang, Gaoxiao
Xu, Lipeng
Wang, Dingyuan
Wang, Liang
Zeng, Xiangping
Wang, Yuqiang
机构：
[1] Jinan Univ, Coll Pharm, Inst New Drug Res, Guangzhou 510632, Guangdong, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 12期
关键词：
Andrographolide derivatives; Synthesis; Antibacterial; Quorum sensing; TO-CELL COMMUNICATION; PSEUDOMONAS-AERUGINOSA; QUORUM; BACTERIA; INFLAMMATION; INHIBITION; ACTIVATION; SYNTHASES; PYOCYANIN; NETWORKS;
D O I：
10.1016/j.bmc.2010.04.094
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of andrographolide derivatives were synthesized through a facile condensation reaction with different carboxylic acids. The new compounds were characterized and screened for their antibacterial activities. A number of the new compounds significantly reduced bacterial quorum sensing virulence factors production in Pseudomonas aeruginosa, essential for pathogenesis. Compound 11b showed the best activity among all the new compounds. (C) 2010 Elsevier Ltd. All rights reserved.
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收藏
页码：4269 / 4274
页数：6
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