Detection of microcystins using electrospray ionization high-field asymmetric waveform ion mobility mass spectrometry/mass spectrometry

被引：0
|
作者：
Ells, B
Froese, K
Hrudey, SE
Purves, RW
Guevremont, R [1 ]
Barnett, DA
机构：
[1] Natl Res Council Canada, Inst Natl Measurement Stand, Ottawa, ON K1A 0R6, Canada
[2] Univ Alberta, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
[3] PE Sciex, Concord, ON L4K 4V8, Canada
来源：
RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2000年 / 14卷 / 16期
关键词：
D O I：
10.1002/1097-0231(20000830)14:16<1538::AID-RCM61>3.0.CO;2-I
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A combination of electrospray ionization, high-field asymmetric waveform ion mobility spectrometry, and mass spectrometry (ESI-FAIMS/MS) was used to analyze standard solutions of microcystins-LR -RR, and -YR. The ability of FAIMS to separate ions in the gas phase reduced the amount of background in the mass spectrum without compromising the absolute signal for these microcystins, This reduction in background resulted in a ten-fold improvement in the signal-to-background ratio over conventional ESI-RIS. Detection limits, using direct infusion, were determined to be 4, 2, and 1 nM for microcystins-LR, -RR, and -YR, respectively. Copyright (C) 2000 John Wiley & Sons, Ltd.
引用
收藏
页码：1538 / 1542
页数：5
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