RISK OF FRACTURE IN PATIENTS WITH CHARCOT-MARIE-TOOTH DISEASE

被引：11

作者：

Pouwels, Sander ^{[1
]}

de Boer, Anthonius ^{[1
]}

Leufkens, Hubert G. M. ^{[1
]}

Weber, Wim E. J. ^{[2
]}

Cooper, Cyrus ^{[3
,4
,5
]}

de Vries, Frank ^{[1
,3
,6
,7
]}

机构：

[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, NL-3584 CG Utrecht, Netherlands

[2] Univ Med Ctr, Dept Neurol Maastricht, Maastricht, Netherlands

[3] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England

[4] Univ Southampton, NIHR Nutr Biomed Res Ctr, Southampton, Hants, England

[5] Univ Oxford, NIHR Musculoskeletal Biomed Res Unit, Oxford, England

[6] Maastricht Univ, Dept Clin Pharm & Toxicol, Med Ctr, Maastricht, Netherlands

[7] Maastricht Univ, Sch CAPHRI, Maastricht, Netherlands

来源：

MUSCLE & NERVE | 2014年 / 50卷 / 06期

关键词：

Charcot-Marie-Tooth disease; cohort study; epidemiology; fracture; osteoporosis; ORAL CORTICOSTEROIDS; ANTIDEPRESSANTS; ANXIOLYTICS; POPULATION; NEUROPATHY; SEDATIVES; DATABASE; CHILDREN; QUALITY;

D O I：

10.1002/mus.24240

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: In this study we evaluated fracture risk in patients with Charcot-Marie-Tooth (CMT) disease. Methods: We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987-2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures. Results: The risk of non-osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01-2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98-1.74) and AHR 1.10 (95% CI 0.69-1.74), respectively]. Conclusions: CMT patients have a 1.5-fold increased risk for non-osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture. Muscle Nerve50: 919-924, 2014

引用

页码：919 / 924

页数：6

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