Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines

被引：124

作者：

Suzen, S ^{[1
]}

Buyukbingol, E ^{[1
]}

机构：

[1] Ankara Univ, Fac Pharm, ECZACILIK, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

来源：

FARMACO | 2000年 / 55卷 / 04期

关键词：

indole; hydantoin; thiohydantoin; anti-cancer activity;

D O I：

10.1016/S0014-827X(00)00028-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

5-(2-Phenyl-3'-indolal)-2-thiohydantoin (PIT) has been evaluated as an anti-cancer compound on several cancer lines organised in to subpanels representing leukemia, melanoma, and cancer of lung, colon, kidney, ovary, breast, prostate and central nervous system by the National Cancer Institute (NCI) anti-cancer drug screen programme. The compound showed inhibitory activity on several cancer cell lines. No information is available on anti-cancer potency of this compound with normal cell lines. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：246 / 248

页数：3

共 18 条

[1] 2-phenylindoles with sulfur containing side chains. Estrogen receptor affinity, antiestrogenic potency, and antitumor activity [J].

Biberger, C ;

vonAngerer, E .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1996, 58 (01) :31-43

[2]

BUYUKBINGOL E, 1994, FARMACO, V49, P443

[3] SYNTHESIS, BIOLOGICAL EVALUATION, AND QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP ANALYSIS OF 2-HYDROXY-1H-ISOINDOLEDIONES AS NEW CYTOSTATIC AGENTS [J].

CHAN, CL ;

LIEN, EJ ;

TOKES, ZA .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (03) :509-514

[4] Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells [J].

Chen, I ;

Safe, S ;

Bjeldanes, L .

BIOCHEMICAL PHARMACOLOGY, 1996, 51 (08) :1069-1076

[5] Synthesis and cytotoxic evaluation of substituted sulfonyl-N-hydroxyguanidine derivatives as potential antitumor agents [J].

Chern, JW ;

Leu, YL ;

Wang, SS ;

Jou, RW ;

Lee, CF ;

Tsou, PC ;

Hsu, SC ;

Liaw, YC ;

Lin, HM .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (14) :2276-2286

[6]

Cover CM, 1999, CANCER RES, V59, P1244

[7]

DIWAN BA, 1988, CANCER RES, V48, P2492

[8] 3,3'-diindolylmethane induces apoptosis in human cancer cells [J].

Ge, XK ;

Yannai, S ;

Rennert, G ;

Gruener, N ;

Fares, FA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 228 (01) :153-158

[9]

GREVER MR, 1992, SEMIN ONCOL, V19, P622

[10] STUDIES ON THE CELLULAR PHARMACOLOGY OF N-(4-METHYLPHENYLSULFONYL)-N'-(4-CHLOROPHENYL)-UREA [J].

HOUGHTON, PJ ;

BAILEY, FC ;

GERMAIN, GS ;

GRINDEY, GB ;

HOWBERT, JJ ;

HOUGHTON, JA .

BIOCHEMICAL PHARMACOLOGY, 1990, 39 (07) :1187-1192

← 1 2 →