Synthesis of 8-substituted pyrazolo[1,5-a]-1,3,5-triazine derivatives by palladium-catalyzed cross-coupling reactions

被引：6

作者：

Popowycz, Florence

Bernard, Philippe

Raboisson, Pierre

Joseph, Benoit

机构：

[1] Univ Lyon 1, CNRS, UMR 5181, Lab Chimie Organ 1, F-69622 Villeurbanne, France

[2] Greenpharma SA, F-45100 Orleans, France

来源：

SYNTHESIS-STUTTGART | 2007年 / 03期

关键词：

purine; bioisosteres; pyrazolo[1,5-a]-1,3,5-triazine; palladium;

D O I：

10.1055/s-2006-958963

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

8-Substituted pyrazolo[1,5-a]-1,3,5-triazine derivatives 6 were prepared from the corresponding 8-iodopyrazolo[1,5-a]1,3,5-triazines 5 through palladium-catalyzed cross-coupling reactions. Several bioisosteres of hypoxanthine drugs 2 were then prepared by final nucleophilic aromatic substitution.

引用

页码：367 / 374

页数：8

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Bernard P., 2004, Novel Substituted Pyrazolo[1,5-a]-1,3,5-Triazine Derivatives and Their Analogs, Pharmaceutical Compositions Containing Same, Use Thereof as Medicine and Methods for Preparing Same, Patent No. [WO 2004/011464, 2004011464]

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