Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus

被引：20

作者：

Kellner, Erinn S. ^{[1
,2
]}

Lee, Pui Y. ^{[1
,2
,3
]}

Li, Yi ^{[1
,2
]}

Switanek, Juliana ^{[1
,2
]}

Zhuang, Haoyang ^{[1
,2
]}

Segal, Mark S. ^{[1
,2
,3
]}

Sobel, Eric S. ^{[1
,2
,4
]}

Satoh, Minoru ^{[1
,2
,4
]}

Reeves, Westley H. ^{[1
,2
,4
]}

机构：

[1] Univ Florida, Div Rheumatol & Clin Immunol, Gainesville, FL 32610 USA

[2] Univ Florida, Ctr Autoimmune Dis, Gainesville, FL 32610 USA

[3] Univ Florida, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32610 USA

[4] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 223卷 / 1-2期

关键词：

Systemic lupus erythematosus; Depression; Fatigue; Type-I interferon; INDUCIBLE GENE-EXPRESSION; CHRONIC HEPATITIS-C; DISEASE-ACTIVITY; PSYCHIATRIC MANIFESTATIONS; COGNITIVE DYSFUNCTION; IFN-ALPHA; ANTIBODIES; SLE; ACTIVATION; RECEPTORS;

D O I：

10.1016/j.jneuroim.2010.03.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with systemic lupus erythematosus (SLE) often suffer from depression and fatigue in addition to the physical manifestations of the autoimmune disease. Elevated production of type-I interferons (IFN-I) has been found in lupus patients and IFN-I can precipitate a variety of neuropsychiatric side effects. This study was conducted to evaluate the relationship between dysregulated IFN-I production and the presence of depression or fatigue in lupus patients. Through cross-sectional and longitudinal analysis we found no significant correlation between abnormal IFN-I levels (as measured by peripheral blood expression of IFN-I-stimulated genes) and neuropsychiatric manifestations. Elevation of endogenous serum IFN-I levels is unlikely to account for the depression and fatigue associated with SLE.

引用

页码：13 / 19

页数：7

共 43 条

[1] Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus [J].