Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity

被引：64

作者：

Hung, Tran Manh ^{[3
]}

Cao Van Thu ^{[4
]}

Nguyen Tien Dat ^{[5
]}

Ryoo, Sung-Woo ^{[6
]}

Lee, Jeong Hyung ^{[6
]}

Kim, Jin Cheol ^{[7
]}

Na, Minkyun ^{[8
]}

Jung, Hyun-Ju ^{[2
]}

Bae, KiHwan ^{[1
]}

Min, Byung Sun ^{[3
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Wonkwang Univ, Dept Oriental Pharm, Jeonbuk 570749, South Korea

[3] Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea

[4] Hanoi Univ Pharm, Hanoi, Vietnam

[5] Vietnamese Acad Sci & Technol, Inst Nat Prod Chem, Hanoi, Vietnam

[6] Kangwon Natl Univ, Coll Nat Sci, Chunchon 200701, South Korea

[7] Korea Res Inst Chem Technol, Taejon 305600, South Korea

[8] Yeungnam Univ, Coll Pharm, Gyeongbuk 712749, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 08期

关键词：

Ophiopogon japonicus; Liliaceae; Homoisoflavonoids; Anti-inflammatory; CONSTITUENTS; EOTAXIN; TUBER; EOSINOPHIL; GLYCOSIDES; CELLS; RECRUITMENT; EXPRESSION; EXTRACT;

D O I：

10.1016/j.bmcl.2010.03.043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new homoiso. avonoids (1-3) were isolated from the roots of Ophiopogon japonicus (Liliaceae). The structures of new metabolites were determined on the basis of spectroscopic analyses including 2D NMR. The anti-inflammatory activities of new compounds (1-3) were investigated by their effects on the release of the inflammatory chemokine eotaxin, stimulated by IL-4 and the combination of IL-4 and TNF-alpha in BEAS-2B cells, which mimics the in vivo conditions in bronchial allergic asthma. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2412 / 2416

页数：5

共 31 条

[1] TERPENOID GLYCOSIDES FROM OPHIOPOGON-JAPONICUS ROOTS [J].

ADINOLFI, M ;

PARRILLI, M ;

ZHU, YX .

PHYTOCHEMISTRY, 1990, 29 (05) :1696-1699

[2] Homoisoflavonoids from Ophiopogon japonicus Ker-Gawler [J].

Anh, NTH ;

Van Sung, T ;

Porzel, A ;

Franke, K ;

Wessjohann, LA .

PHYTOCHEMISTRY, 2003, 62 (07) :1153-1158

[3]

ASANO T, 1983, J CHEM PHARM B, V41, P566

[4] THE ROLE OF ADHESION MOLECULES IN HUMAN EOSINOPHIL AND BASOPHIL RECRUITMENT [J].

BOCHNER, BS ;

SCHLEIMER, RP .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1994, 94 (03) :427-438

[5]

Chang HM, 1986, PHARM APPL CHINESE M, P543

[6] Five new homoisoflavonoids from the tuber of Ophiopogon japonicus [J].

Chang, JM ;

Shen, CC ;

Huang, YL ;

Chien, MY ;

Ou, JC ;

Shieh, BJ ;

Chen, CC .

JOURNAL OF NATURAL PRODUCTS, 2002, 65 (11) :1731-1733

[7] cis-Eudesmane sesquiterpene glycosides from Liriope muscari and Ophiopogon japonicus [J].

Cheng, ZH ;

Wu, T ;

Bligh, SWA ;

Bashall, A ;

Yu, BY .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (10) :1761-1763

[8]

Chiappara G, 2001, CURR OPIN ALLERGY CL, V1, P85, DOI 10.1097/01.all.0000010990.97765.a1

[9]

Chiu Pu-Rong, 2008, Pediatrics and Neonatology, V49, P135, DOI 10.1016/S1875-9572(08)60028-5

[10]

DO TL, 1991, GLOSSARY VIETNAMESE

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