Birth weight and adult income: An examination of mediation through adult height and body mass

被引：4

作者：

Pehkonen, Jaakko ^{[1
]}

Viinikainen, Jutta ^{[1
]}

Kari, Jaana T. ^{[1
]}

Boeckerman, Petri ^{[1
,2
,3
]}

Lehtimaeki, Terho ^{[4
,5
]}

Raitakari, Olli ^{[6
,7
,8
,9
]}

机构：

[1] Univ Jyvaskyla, Jyvaskyla Univ Sch Business & Econ, Jyvaskyla, Finland

[2] Labour Inst Econ Res, Helsinki, Finland

[3] IZA, Bonn, Germany

[4] Finnish Cardiovasc Res Ctr, Dept Clin Chem, Tampere, Finland

[5] Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland

[6] Univ Turku, Ctr Populat Hlth Res, Turku, Finland

[7] Turku Univ Hosp, Turku, Finland

[8] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland

[9] Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland

来源：

HEALTH ECONOMICS | 2021年 / 30卷 / 10期

基金：

芬兰科学院; 欧洲研究理事会;

关键词：

birth weight; body mass index; height; income; mediation; multivariable Mendelian randomization; polygenic instrument; LABOR-MARKET; MENDELIAN RANDOMIZATION; INSTRUMENTAL VARIABLES; OBESITY; CHILDHOOD; STATURE; PITFALLS; IMPACT; POWER; RISK;

D O I：

10.1002/hec.4387

中图分类号：

F [经济];

学科分类号：

02 ;

摘要：

This paper examines the causal links between early human endowments and socioeconomic outcomes in adulthood. We use a genotyped longitudinal survey (Cardiovascular Risk in Young Finns Study) that is linked to the administrative registers of Statistics Finland. We focus on the effect of birth weight on income via two anthropometric mediators: body mass index (BMI) and height in adulthood. We find that (i) the genetic instruments for birth weight, adult height, and adult BMI are statistically powerful; (ii) there is a robust total effect of birth weight on income for men but not for women; (iii) the total effect of birth weight on income for men is partly mediated via height but not via BMI; and (iv) the share of the total effect mediated via height is substantial, of approximately 56%.

引用

页码：2383 / 2398

页数：16

共 70 条

[1] Childhood Circumstances and Adult Outcomes: Act II [J].

Almond, Douglas ;

Currie, Janet ;

Duque, Valentina .

JOURNAL OF ECONOMIC LITERATURE, 2018, 56 (04) :1360-1446

[2] A map of human genome variation from population-scale sequencing [J].

Altshuler, David ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Collins, Francis S. ;

De la Vega, Francisco M. ;

Donnelly, Peter ;

Egholm, Michael ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Knoppers, Bartha M. ;

Lander, Eric S. ;

Lehrach, Hans ;

Mardis, Elaine R. ;

McVean, Gil A. ;

Nickerson, DebbieA. ;

Peltonen, Leena ;

Schafer, Alan J. ;

Sherry, Stephen T. ;

Wang, Jun ;

Wilson, Richard K. ;

Gibbs, Richard A. ;

Deiros, David ;

Metzker, Mike ;

Muzny, Donna ;

Reid, Jeff ;

Wheeler, David ;

Wang, Jun ;

Li, Jingxiang ;

Jian, Min ;

Li, Guoqing ;

Li, Ruiqiang ;

Liang, Huiqing ;

Tian, Geng ;

Wang, Bo ;

Wang, Jian ;

Wang, Wei ;

Yang, Huanming ;

Zhang, Xiuqing ;

Zheng, Huisong ;

Lander, Eric S. ;

Altshuler, David L. ;

Ambrogio, Lauren ;

Bloom, Toby ;

Cibulskis, Kristian ;

Fennell, Tim J. ;

Gabriel, Stacey B. .

NATURE, 2010, 467 (7319) :1061-1073

[3] GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI [J].

Alves, Alexessander Couto ;

De Silva, N. Maneka G. ;

Karhunen, Ville ;

Sovio, Ulla ;

Das, Shikta ;

Taal, H. Rob ;

Warrington, Nicole M. ;

Lewin, Alexandra M. ;

Kaakinen, Marika ;

Cousminer, Diana L. ;

Thiering, Elisabeth ;

Timpson, Nicholas J. ;

Bond, Tom A. ;

Lowry, Estelle ;

Brown, Christopher D. ;

Estivill, Xavier ;

Lindi, Virpi ;

Bradfield, Jonathan P. ;

Geller, Frank ;

Speed, Doug ;

Coin, Lachlan J. M. ;

Loh, Marie ;

Barton, Sheila J. ;

Beilin, Lawrence J. ;

Bisgaard, Hans ;

Bonnelykke, Klaus ;

Alili, Rohia ;

Hatoum, Ida J. ;

Schramm, Katharina ;

Cartwright, Rufus ;

Charles, Marie-Aline ;

Salerno, Vincenzo ;

Clement, Karine ;

Claringbould, Annique A. J. ;

van Duijn, Cornelia M. ;

Moltchanova, Elena ;

Eriksson, Johan G. ;

Elks, Cathy ;

Feenstra, Bjarke ;

Flexeder, Claudia ;

Franks, Stephen ;

Frayling, Timothy M. ;

Freathy, Rachel M. ;

Elliott, Paul ;

Widen, Elisabeth ;

Hakonarson, Hakon ;

Hattersley, Andrew T. ;

Rodriguez, Alina ;

Banterle, Marco ;

Heinrich, Joachim .

SCIENCE ADVANCES, 2019, 5 (09)

[4]

[Anonymous], 2011, OXFORD HDB SOCIAL SC, DOI DOI 10.1093/OXFORDHB/9780199736362.013.0032

[5] FETAL ORIGINS OF CORONARY HEART-DISEASE [J].

BARKER, DJP .

BRITISH MEDICAL JOURNAL, 1995, 311 (6998) :171-174

[6] Estimates of healthcare spending for preterm and low-birthweight infants in a commercially insured population: 2008-2016 [J].

Beam, Andrew L. ;

Fried, Inbar ;

Palmer, Nathan ;

Agniel, Denis ;

Brat, Gabriel ;

Fox, Kathe ;

Kohane, Isaac ;

Sinaiko, Anna ;

Zupancic, John A. F. ;

Armstrong, Joanne .

JOURNAL OF PERINATOLOGY, 2020, 40 (07) :1091-1099

[7] Returns to birthweight [J].

Behrman, JR ;

Rosenzweig, MR .

REVIEW OF ECONOMICS AND STATISTICS, 2004, 86 (02) :586-601

[8] Genetics and the geography of health, behaviour and attainment [J].

Belsky, Daniel W. ;

Caspi, Avshalom ;

Arseneault, Louise ;

Corcoran, David L. ;

Domingue, Benjamin W. ;

Harris, Kathleen Mullan ;

Houts, Renate M. ;

Mill, Jonathan S. ;

Moffitt, Terrie E. ;

Prinz, Joseph ;

Sugden, Karen ;

Wertz, Jasmin ;

Williams, Benjamin ;

Odgers, Candice L. .

NATURE HUMAN BEHAVIOUR, 2019, 3 (06) :576-586

[9] The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development [J].

Belsky, Daniel W. ;

Moffitt, Terrie E. ;

Corcoran, David L. ;

Domingue, Benjamin ;

Harrington, HonaLee ;

Hogan, Sean ;

Houts, Renate ;

Ramrakha, Sandhya ;

Sugden, Karen ;

Williams, Benjamin S. ;

Poulton, Richie ;

Caspi, Avshalom .

PSYCHOLOGICAL SCIENCE, 2016, 27 (07) :957-972

[10] Genetics in Population Health Science: Strategies and Opportunities [J].

Belsky, Daniel W. ;

Moffitt, Terrie E. ;

Caspi, Avshalom .

AMERICAN JOURNAL OF PUBLIC HEALTH, 2013, 103 :73-83

← 1 2 3 4 5 6 7 →