Circulating miRNAs in nontumoral liver diseases

被引：19
作者：
do Amaral, Alex Evangelista [1 ]
Cisilotto, Julia [1 ]
Creczynski-Pasa, Tania Beatriz [1 ]
Schiavon, Leonardo de Lucca [2 ]
机构：
[1] Univ Fed Santa Catarina, Dept Pharmaceut Sci, Delfino Conti St, BR-88040370 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Div Gastroenterol, Dept Internal Med, Maria Flora Pausewang St, BR-88036800 Florianopolis, SC, Brazil
来源：
PHARMACOLOGICAL RESEARCH | 2018年 / 128卷
关键词：
Circulating miRNA; Liver cirrhosis; Liver diseases; MicroRNA; miRNA; CHRONIC HEPATITIS-C; B-VIRUS INFECTION; RNA-INTERFERENCE; SERUM MICRORNA-122; POTENTIAL BIOMARKERS; CIRRHOSIS MORTALITY; COST-EFFECTIVENESS; MESSENGER-RNAS; UP-REGULATION; EXPRESSION;
D O I：
10.1016/j.phrs.2017.10.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In recent years, there has been increasing interest in finding new biomarkers for diagnosis and prognostication of liver diseases. MicroRNAs (miRNAs) are small noncoding RNA molecules involved in the regulation of gene expression and have been studied in relation to several conditions, including liver disease. Mature miRNAs can reach the bloodstream by passive release or by incorporation into lipoprotein complexes or microvesicles, and have stable and reproducible concentrations among individuals. In this review, we summarize studies involving circulating miRNAs sourced from the serum or plasma of patients with nontumoral liver diseases in attempt to bring insights in the use of miRNAs as biomarkers for diagnosis, as well as for prognosis of such diseases. In addition, we present pre-analytical aspects involving miRNA analysis and strategies for normalization of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) data related to the studies evaluated. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：274 / 287
页数：14
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