Successful Treatment of POEMS Syndrome Complicated by Severe Congestive Heart Failure with Thalidomide

被引：31

作者：

Inoue, Daichi ^{[1
]}

Kato, Aiko ^{[1
]}

Tabata, Sumie ^{[1
]}

Kitai, Takeshi ^{[2
]}

Takiuchi, Yoko ^{[1
]}

Kimura, Takaharu ^{[1
]}

Shimoji, Sonoko ^{[1
]}

Mori, Minako ^{[1
]}

Nagai, Yuya ^{[1
]}

Togami, Katsuhiro ^{[1
]}

Matsushita, Akiko ^{[1
]}

Nagai, Kenichi ^{[1
]}

Maruoka, Hayato ^{[3
]}

Imai, Yukihiro ^{[4
]}

Beppu, Minako ^{[5
]}

Kawamoto, Michi ^{[5
]}

Takahashi, Takayuki ^{[1
]}

机构：

[1] Kobe City Med Ctr Gen Hosp, Dept Hematol & Clin Immunol, Kobe, Hyogo, Japan

[2] Kobe City Med Ctr Gen Hosp, Dept Cardiol, Kobe, Hyogo, Japan

[3] Kobe City Med Ctr Gen Hosp, Dept Clin Lab, Kobe, Hyogo, Japan

[4] Kobe City Med Ctr Gen Hosp, Dept Clin Pathol, Kobe, Hyogo, Japan

[5] Kobe City Med Ctr Gen Hosp, Dept Neurol, Kobe, Hyogo, Japan

来源：

INTERNAL MEDICINE | 2010年 / 49卷 / 05期

关键词：

POEMS syndrome; thalidomide; congestive heart failure; VEGF; CROW-FUKASE-SYNDROME; STEM-CELL TRANSPLANTATION; OF-THE-LITERATURE; PULMONARY-HYPERTENSION; MULTIPLE-MYELOMA; CARDIOMYOPATHY; POLYNEUROPATHY; DEXAMETHASONE; BEVACIZUMAB; VEGF;

D O I：

10.2169/internalmedicine.49.2833

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 55-year-old woman was diagnosed with POEMS syndrome; however, we could not perform high-dose chemotherapy with autologous peripheral blood stem cell transplantation (auto-PBSCT) because of rapidly progressive congestive heart failure. Thus, we treated the patient with thalidomide plus dexamethasone, which brought about a marked improvement of systolic dysfunction, POEMS syndrome-related symptoms and the serum concentrations of vascular endothelial growth factor. Subsequently, we safely performed high-dose chemotherapy with auto-PBCST. This report strongly suggests that thalidomide is effective for POEMS syndrome, even if complicated by congestive heart failure which is considered to be related to POEMS syndrome.

引用

页码：461 / 466

页数：6

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