Heat-induced changes of the optical tissue properties of liver tissue

被引：2

作者：

Ritz, JP ^{[1
]}

Roggan, A ^{[1
]}

Isbert, C ^{[1
]}

Albrecht, D ^{[1
]}

Germer, CT ^{[1
]}

Muller, GJ ^{[1
]}

Buhr, HJ ^{[1
]}

机构：

[1] Free Univ Berlin, Klinikum Benjamin Franklin, Dept Gen Vasc & Thorac Surg, D-12200 Berlin, Germany

来源：

PHOTOTHERMAL THERAPIES IN MEDICINE, PROCEEDINGS OF | 1998年 / 3193卷

关键词：

optical tissue properties; laser-induced thermotherapy; double integrating sphere technique; temperature behavior; absorption; penetration depth; irradiation planning;

D O I：

10.1117/12.300823

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

For prediction of the effectiveness of laser-induced thermotherapy of liver metastases and for the understanding and optimal use of laser applications in medicine, especially for dosimetrical questions, the knowledge of the specific optical properties and their thermo-induced changes is important. In our study we were able to evaluate the optical properties of human liver tissue and metastatic tissue. Furthermore, we investigated the dynamic temperature behavior between 45 degrees C and 80 degrees C at three different exposure times using a double-integrating sphere system. We found significant differences between normal and metastatic tissue resulting in a higher optical penetration depth in the tumorous tissue. During the coagulation the absorption coefficient, anisotropy and optical penetration depth decreased significantly in the temperature range from 45 degrees to 65 degrees C, whereas the scattering coefficient increased. Above and below this temperature range the changes of the optical properties were not significant. The coagulation rate differed between the exposure times.

引用

页码：80 / 87

页数：8