Cytokines and T-cell homeostasis

被引:226
作者
Boyman, Onur
Purton, Jared F.
Surh, Charles D.
Sprent, Jonathan
机构
[1] Univ Lausanne Hosp, Div Immunol & Allergy, CH-1011 Lausanne, Switzerland
[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
[3] Garvan Inst Med Res, Darlinghurst, NSW 2010, Australia
基金
美国国家卫生研究院; 英国医学研究理事会;
关键词
D O I
10.1016/j.coi.2007.04.015
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Homeostasis of T cells can be defined as the ability of the immune system to maintain normal T-cell counts and to restore T-cell numbers following T-cell depletion or expansion. These processes are governed by extrinsic signals, most notably cytokines. Two members of the common gamma chain family of cytokines, interleukin (IL)-7 and IL-15, are central to homeostatic proliferation and survival of mature CD4(+) and CD8(+) T cells. Recent evidence suggests that other cytokines, including IL-2, IL-10, IL-12, interferons and TGF-P, as well as the transcription factors T-bet and eomesodermin all play important but different roles at distinct stages of T-cell homeostasis.
引用
收藏
页码:320 / 326
页数:7
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