Low Fouling, Peptoid-Coated Polysulfone Hollow Fiber Membranes-the Effect of Grafting Density and Number of Side Chains

The development of low fouling membranes to minimize protein adsorption has relevance in various biomedical applications. Here, electrically neutral peptoids containing 2-methoxyethyl glycine (NMEG) side chains were attached to polysulfone hollow fiber membranes via polydopamine. The number of side chains and grafting density were varied to determine the effect on coating properties and the ability to prevent fouling. NMEG peptoid coatings have high hydrophilicity compared to unmodified polysulfone membranes. The extent of biofouling was evaluated using bovine serum albumin, as well as platelet adhesion. The results suggest that both the number of side chains and grafting density play a role in the surface properties that drive biofouling. Protein adsorption decreased with increasing peptoid grafting density and is lowest above a critical grafting density specific to peptoid chain length. Our findings show that the optimization of grafting density and hydration of the surface are important factors for achieving the desired antifouling performance.