Direct Access to Nitrogen Bi-heteroarenes via Iridium-Catalyzed Hydrogen-Evolution Cross-Coupling Reaction

被引：25

作者：

Chen, Chunlian ^{[1
]}

Chen, Xiuwen ^{[1
]}

Zhao, He ^{[1
]}

Jiang, Huanfeng ^{[1
]}

Zhang, Min ^{[1
]}

机构：

[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Wushan Rd 381, Guangzhou 510641, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 13期

基金：

中国国家自然科学基金;

关键词：

H BOND ARYLATIONS; C-H; ROOM-TEMPERATURE; INDOLES; DERIVATIVES; ALCOHOLS; FUNCTIONALIZATION; ALKYLATION; QUINOLINES; PYRROLES;

D O I：

10.1021/acs.orglett.7b01349

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Through cooperative actions of iridium catalyst and NaOTf additive we report a new direct access to nitrogen bi-heteroarenes via hydrogen-evolution cross-coupling of the beta-site of indoles/pyrrole with the alpha-site of N-heteroarenes. The reaction proceeds in an atom- and redox-economic fashion together with the merits of an easily available catalyst system, broad substrate scope, excellent functional tolerance, and no need for external oxidants, offering a practical way to create pi-conjugated systems.

引用

页码：3390 / 3393

页数：4

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