Redistribution of CD8+T cell subsets in metastatic renal cell carcinoma patients treated with anti-PD-1 therapy

被引：3

作者：

De Biasi, Sara ^{[1
]}

Guida, Annalisa ^{[2
,3
]}

Lo Tartaro, Domenico ^{[1
,4
]}

Fanelli, Martina ^{[1
,3
]}

Depenni, Roberta ^{[3
]}

Dominici, Massimo ^{[1
,3
]}

Finak, Greg ^{[5
]}

Porta, Camillo ^{[6
]}

Paolini, Annamaria ^{[1
,4
]}

Borella, Rebecca ^{[1
,4
]}

Bertoldi, Carlo ^{[7
]}

Cossarizza, Andrea ^{[1
,8
]}

Sabbatini, Roberto ^{[3
]}

Gibellini, Lara ^{[1
]}

机构：

[1] Univ Modena & Reggio Emilia, Dept Med & Surg Sci Children & Adults, Emilia Romagna, Italy

[2] Azienda Osped Santa Maria, Terni, Italy

[3] Univ Modena & Reggio Emilia, Dept Oncol, Modena, Italy

[4] Univ Modena & Reggio Emilia, Clin & Expt Med PhD Program, Modena, Italy

[5] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[6] Univ Bari, Chair Oncol, Bari, Italy

[7] Univ Modena & Reggio Emilia, Dept Surg Med Dent & Morphol Sci, Emilia Romagna, Italy

[8] Natl Inst Cardiovasc Res, Bologna, Italy

来源：

CYTOMETRY PART A | 2022年 / 101卷 / 07期

关键词：

anti-PD-1; therapy; mRCC; single-cells technologies; T cells; unsupervised cluster analysis; T-CELLS; NIVOLUMAB;

D O I：

10.1002/cyto.a.24562

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Renal-cell carcinoma (RCC) is responsible for the majority of tumors arising from the kidney parenchyma. Although a progressive improvement in median overall survival has been observed after the introduction of anti-PD-1 therapy, many patients do not benefit from this treatment. Therefore, we have investigated T cell dynamics to find immune modification induced by anti-PD-1 therapy. Here, we show that, after therapy, RCC patients (5 responders and 14 nonresponders) are characterized by a redistribution of different subsets across the memory T cell compartment.

引用

页码：597 / 605

页数：9

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