Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease

被引：139
作者：
Timmermann, L
Wojtecki, L
Gross, J
Lehrke, R
Voges, J
Maarouf, M
Treuer, H
Sturm, V
Schnitzler, A
机构：
[1] Univ Dusseldorf, MEG Lab, Dept Neurol, D-40225 Dusseldorf, Germany
[2] Univ Cologne, Dept Stereotact Neurosurg, Cologne, Germany
来源：
MOVEMENT DISORDERS | 2004年 / 19卷 / 11期
关键词：
tremor; Parkinson's disease; UPDRS; akinesia; deep brain stimulation; synchronization; oscillations;
D O I：
10.1002/mds.20198
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation of electrodes. STN stimulation at 10 Hz induced significant worsening of motor symptoms, especially akinesia, compared with no stimulation and therapeutic stimulation ( greater than or equal to130 Hz). This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD. (C) 2004 Movement Disorder Society.
引用
收藏
页码：1328 / 1333
页数：6
相关论文
共 14 条
[1]   THE PRIMATE SUBTHALAMIC NUCLEUS .2. NEURONAL-ACTIVITY IN THE MPTP MODEL OF PARKINSONISM [J].
BERGMAN, H ;
WICHMANN, T ;
KARMON, B ;
DELONG, MR .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (02) :507-520
[2]   What do the basal ganglia do? [J].
Brown, P ;
Marsden, CD .
LANCET, 1998, 351 (9118) :1801-1804
[3]   Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease [J].
Brown, P ;
Oliviero, A ;
Mazzone, P ;
Insola, A ;
Tonali, P ;
Di Lazzaro, V .
JOURNAL OF NEUROSCIENCE, 2001, 21 (03) :1033-1038
[4]   THALAMIC-STIMULATION AND SUPPRESSION OF PARKINSONIAN TREMOR - EVIDENCE OF A CEREBELLAR DEACTIVATION USING POSITRON EMISSION TOMOGRAPHY [J].
DEIBER, MP ;
POLLAK, P ;
PASSINGHAM, R ;
LANDAIS, P ;
GERVASON, C ;
CINOTTI, L ;
FRISTON, K ;
FRACKOWIAK, R ;
MAUGUIERE, F ;
BENABID, AL .
BRAIN, 1993, 116 :267-279
[5]  
Demeret S, 1999, NEUROLOGY, V52, pA406
[6]   OPTIMIZATION AND EVALUATION OF LANDMARK-BASED IMAGE CORRELATION [J].
ENDE, G ;
TREUER, H ;
BOESECKE, R .
PHYSICS IN MEDICINE AND BIOLOGY, 1992, 37 (01) :261-271
[7]   Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease [J].
Limousin, P ;
Krack, P ;
Pollak, P ;
Benazzouz, A ;
Ardouin, C ;
Hoffmann, D ;
Benabid, AL .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (16) :1105-1111
[8]   The impact on Parkinson's disease of electrical parameter settings in STN stimulation [J].
Moro, E ;
Esselink, RJA ;
Xie, J ;
Hommel, M ;
Benabid, AL ;
Pollak, P .
NEUROLOGY, 2002, 59 (05) :706-713
[9]  
S Fahn, 1987, RECENT DEV PARKINSON
[10]   STEREOTAXIC LOCALIZATION OF INTRACRANIAL TARGETS [J].
SIDDON, RL ;
BARTH, NH .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1987, 13 (08) :1241-1246
12