Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells

被引：87

作者：

Wongrakpanich, Amaraporn ^{[1
,2
,3
]}

Mudunkotuwa, Imali A. ^{[4
]}

Geary, Sean M. ^{[1
]}

Morris, Angie S. ^{[1
,4
]}

Mapuskar, Kranti A. ^{[5
]}

Spitz, Douglas R. ^{[5
]}

Grassian, Vicki H. ^{[4
,6
,7
,8
]}

Salem, Aliasger K. ^{[1
]}

机构：

[1] Univ Iowa, Coll Pharm, Dept Pharmaceut Sci & Expt Therapeut, 115 S Grand Ave,S228 PHAR, Iowa City, IA 52242 USA

[2] Mahidol Univ, Dept Pharm, Fac Pharm, Bangkok 10400, Thailand

[3] Mahidol Univ, Fac Pharm, Ctr Excellence Innovat Drug Delivery & Nanomed, Bangkok 10400, Thailand

[4] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA

[5] Univ Iowa, Carver Coll Med, Dept Radiat Oncol, Iowa City, IA 52242 USA

[6] Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr, La Jolla, CA 92093 USA

[7] Univ Calif San Diego, Dept Nanoengn, 9500 Gilman Dr, La Jolla, CA 92093 USA

[8] Univ Calif San Diego, Scripps Inst Oceanog, 9500 Gilman Dr, La Jolla, CA 92093 USA

来源：

ENVIRONMENTAL SCIENCE-NANO | 2016年 / 3卷 / 02期

关键词：

CUO NANOPARTICLES; ENVIRONMENTAL IMPLICATIONS; DAPHNIA-MAGNA; TOXICITY; NANO; DISSOLUTION; PARTICLES; RELEASE; IRON; ZNO;

D O I：

10.1039/c5en00271k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities. In this study, we compared the in vitro cytotoxicity of CuO NPs of two distinct sizes (4 and 24 nm) using the A549 human lung cell line. Despite possessing similar surface and core oxide compositions, 24 nm CuO NPs were significantly more cytotoxic than 4 nm CuO NPs. The difference in size may have affected the rate of entry of NPs into the cell, potentially influencing the amount of intracellular dissolution of Cu2+ and causing a differential impact on cytotoxicity.

引用

页码：365 / 374

页数：10

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