Exosomal microRNAs and exosomal long non-coding RNAs in gynecologic cancers

被引：69

作者：

Hashemipour, Maryam ^{[1
]}

Boroumand, Homa ^{[1
]}

Mollazadeh, Samaneh ^{[2
]}

Tajiknia, Vida ^{[3
]}

Nourollahzadeh, Zahra ^{[4
]}

Borj, Mina Rohani ^{[5
]}

Pourghadamyari, Hossein ^{[6
]}

Rahimian, Neda ^{[7
]}

Hamblin, Michael R. ^{[8
]}

Mirzaei, Hamed ^{[9
]}

机构：

[1] Kashan Univ Med Sci, Sch Med, Kashan, Iran

[2] North Khorasan Univ, Nat Prod & Med Plants Res Ctr, Bojnurd, Iran

[3] Iran Univ Med Sci, Sch Med, Dept Surg, Tehran, Iran

[4] Islamic Azad Univ, Dept Biol Sci, Ahar, Iran

[5] Mashhad Univ Med Sci, Dept Biochem, Fac Med, Mashhad, Razavi Khorasan, Iran

[6] Kerman Univ Med Sci, Dept Clin Biochem, Afzalipour Sch Med, Kerman, Iran

[7] Iran Univ Med Sci IUMS, Inst Endocrinol & Metab, Endocrine Res Ctr, Tehran, Iran

[8] Univ Johannesburg, Laser Res Ctr, Fac Hlth Sci, ZA-2028 Doornfontein, South Africa

[9] Kashan Univ Med Sci, Inst Basic Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran

来源：

GYNECOLOGIC ONCOLOGY | 2021年 / 161卷 / 01期

关键词：

Gynecologic cancers; MicroRNAs; Long non-coding RNAs; Exosome; EPITHELIAL OVARIAN-CANCER; TUMOR-DERIVED EXOSOMES; OF-THE-ART; CERVICAL-CANCER; CELLULAR ACCUMULATION; DIAGNOSTIC BIOMARKERS; DNA-DAMAGE; METASTASIS; CARCINOMA; CISPLATIN;

D O I：

10.1016/j.ygyno.2021.02.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

serve key biological roles via various mechanisms, such as splicing regulation, chromatin rearrangement, translation regulation, cell-cycle control, genetic imprinting and mRNA decay. Besides, miRNAs govern gene expression by modulation of mRNAs and lncRNAs degradation, suggestive of needing more research in this field. Generally, driving gynecological cancers pathways by miRNAs and lncRNAs lead to the current improvement in cancer-related technologies. Exosomes are extracellular microvesicles which can carry cargo molecules among cells. In recent years, more studies have been focused on exosomal non-coding RNAs (exo-ncRNAs) and exosomal microRNAs (exo-miRs) because of being natural carriers of lnc RNAs and microRNAs via programmed process. In this review we summarized recent reports concerning the function of exosomal microRNAs and Gynecologic cancer isa group of any malignancies affecting reproductive tissues and organs of women, including ovaries, uterine, cervix, vagina, vulva, and endometrium. Several types of molecular mechanisms are associated with the progression of gynecologic cancers. Among it can be referred to the most widely studied non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs) and long ncRNAs (lncRNAs). As yet, lncRNAs are known to Gynecologic cancer isa group of any malignancies affecting reproductive tissues and organs of women, including ovaries, uterine, cervix, vagina, vulva, and endometrium. Several types of molecular mechanisms are associated with the progression of gynecologic cancers. Among it can be referred to the most widely studied non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs) and long ncRNAs (lncRNAs). As yet, lncRNAs are known to serve key biological roles via various mechanisms, such as splicing regulation, chromatin rearrangement, translation regulation, cell-cycle control, genetic imprinting and mRNA decay. Besides, miRNAs govern gene expression by modulation of mRNAs and lncRNAs degradation, suggestive of needing more research in this field. Generally, driving gynecological cancers pathways by miRNAs and lncRNAs lead to the current improvement in cancer-related technologies. Exosomes are extracellular microvesicles which can carry cargo molecules among cells. In recent years, more studies have been focused on exosomal non-coding RNAs (exo-ncRNAs) and exosomal microRNAs (exo-miRs) because of being natural carriers of lnc RNAs and microRNAs via programmed process. In this review we summarized recent reports concerning the function of exosomal microRNAs and exosomal long non-coding RNAs in gynecological cancers. (c) 2021 Elsevier Inc. All rights reserved.

引用

页码：314 / 327

页数：14