Sporadic Creutzfeldt-Jakob disease with MM1-type prion protein and plaques

被引：17

作者：

Ishida, C

Kakishima, A

Okino, S

Furukawa, Y

Kano, M

Oda, Y

Nakanishi, I

Makifuchi, T

Kitamoto, T

Yamada, M

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Dept Neurol & Neurobiol Aging, Kanazawa, Ishikawa 9208640, Japan

[2] Kanazawa Univ, Grad Sch Med Sci, Dept Mol & Cellular Pathol, Kanazawa, Ishikawa 9208640, Japan

[3] Natl Saigata Hosp, Dept Clin Res, Niigata, Japan

[4] Tohoku Univ, Sch Med, Dept Neurol Sci, Sendai, Miyagi 980, Japan

来源：

NEUROLOGY | 2003年 / 60卷 / 03期

关键词：

D O I：

10.1212/01.WNL.0000044403.41041.A4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report a 75-year-old woman with atypical sporadic Creutzfeldt-Jakob disease (CJD) characterized by MM1-type prion protein (PrP) (methionine homozygosity at codon 129 in the PrP gene and type-1 protease-resistant PrP) and PrP plaques. This patient is the first case of sporadic CJD with plaque-forming MM1-type PrP, suggesting either a shared prion strain with the plaque-forming subset of dural graft-associated CJD or shared host genetic factors that are unrelated to the PrP genotype.

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页码：514 / 517

页数：4

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