Application of focused microwaves to the scale-up of solvent-free organic reactions

被引：76

作者：

Cléophax, J

Liagre, M

Loupy, A

Petit, A

机构：

[1] Univ Paris 11, Lab React Select Supports, CNRS, UMR 8615, F-91405 Orsay, France

[2] CNRS, Inst Chim Subst Nat, F-91190 Gif Sur Yvette, France

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2000年 / 4卷 / 06期

关键词：

D O I：

10.1021/op000031e

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A Series of typical solvent-free reactions have been safely and beneficially scaled-up to several hundred grams in a larger batch reactor (Synthewave 1000) with yields equivalent to those obtained under similar conditions (temperature, reaction time) in laboratory-scale experiments (Synthewave 402). They concern potassium acetate alkylation, regioselective phenacylation of 1,2,4-triazole, deethylation of 2 ethoxy-anisole, and typical examples in carbohydrate chemistry (peracetylation, glycosylation, saponification, halogenation, and epoxidation of D-glucopyranosides).

引用

页码：498 / 504

页数：7

共 27 条

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ABENHAIM D, 1994, HETEROCYCLES, V38, P793

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