Innate lymphoid cells

被引：4
作者：
Crinier, Adeline [1 ]
Viant, Charlotte [1 ]
Girard-Madoux, Mathilde [1 ]
Vivier, Eric [1 ,2 ]
机构：
[1] Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France
[2] Hop La Timone, APHM, Serv Immunol, Marseille, France
来源：
M S-MEDECINE SCIENCES | 2017年 / 33卷 / 05期
关键词：
NK CELLS; T-CELL; DIFFERENTIATION; PRECURSORS; INFLAMMATION; MACROPHAGES; REDUNDANCY; CYTOKINES; IMMUNITY; SUBSETS;
D O I：
10.1051/medsci/20173305018
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Innate Lymphoid Cells (ILC) are tissue-resident effector lymphocytes that differ from the B and T lymphocytes subsets since they lack specific antigen receptors derived from gene rearrangements. They can be divided into two groups, cytotoxic ILC (NK cells) which are dependent on the transcription factors Eomes and T-bet and produce IFN-γ, and helper-like ILC (ILC1, ILC2, ILC3) which are dependent on T-bet, GATA-3 or RORγT and produce IFN-γ, IL-5/IL-13 or IL-17/IL-22 respectively. Although they were described recently, ILC are the subject of a large number of studies that characterize their role as one of the first effectors of the innate immune response as well as in the development of a wide number of inflammatory disorders. © 2017 médecine/sciences - Inserm.
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收藏
页码：534 / 542
页数：9
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