Electrospun nanofibers for cancer diagnosis and therapy

被引：134
作者：
Chen, Zhou [1 ,2 ]
Chen, Zhaofeng [1 ]
Zhang, Aili [2 ]
Hu, Jiaming [2 ]
Wang, Xinmei [2 ]
Yang, Zhaogang [2 ]
机构：
[1] Nanjing Univ Aeronaut & Astronaut, Coll Mat Sci & Technol, Nanjing 210016, Peoples R China
[2] Ohio State Univ, Nanoscale Sci & Engn Ctr, Columbus, OH 43210 USA
来源：
BIOMATERIALS SCIENCE | 2016年 / 4卷 / 06期
关键词：
FUNCTIONAL COMPOSITE NANOFIBERS; LOCAL-DRUG DELIVERY; SILICA NANOPARTICLES; SENSITIVE DETECTION; ANTITUMOR EFFICACY; WO3; NANOFIBERS; LUNG-CANCER; FABRICATION; BIOMARKER; HYPERTHERMIA;
D O I：
10.1039/c6bm00070c
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The advent of nanotechnology has provided unprecedented opportunities for nanomedicine. Electrospun nanofibers have some astounding features such as high loading capacity, extremely large surface area and porosity, high encapsulation efficiency, ease of modification, combination of diverse therapies, low cost and great benefits. These remarkable structure-dependent properties have far reaching application potential in cancer diagnosis and therapy such as ultra-sensitive sensing systems for point-of-care cancer detection, targeted cancer cell capture, and functional and smart anticancer drug delivery systems. This review summarizes the principal mechanism of electrospun nanofibers and a variety of modified electrospun nanofibers, illustrates their application in biosensors for cancer detection, and enumerates their application in implantable drug delivery for cancer therapy.
引用
收藏
页码：922 / 932
页数：11
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