Expression of tissue factor in canine mammary tumours and correlation with grade, stage and markers of haemostasis and inflammation

被引：9

作者：

Andreasen, E. B. ^{[1
]}

Nielsen, O. L. ^{[2
]}

Tranholm, M. ^{[3
]}

Knudsen, T. ^{[4
]}

Kristensen, A. T. ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet Clin & Anim Sci, Dyrlaegevej 16, DK-1870 Frederiksberg C, Denmark

[2] Univ Copenhagen, Fac Hlth & Med Sci, Sect Pathol, Dept Vet Dis Biol, DK-1870 Frederiksberg C, Denmark

[3] Novo Nordisk AS, Haemophilia Pharmacol, Biopharmaceut Res Unit, Malov, Denmark

[4] Novo Nordisk AS, In Vivo Haemophilia Pharmacol, Biopharmaceut Res Unit, Malov, Denmark

来源：

VETERINARY AND COMPARATIVE ONCOLOGY | 2016年 / 14卷 / 02期

关键词：

dog; haemostasis; mammary tumour; tissue factor; FACTOR-ACTIVATED THROMBOELASTOGRAPHY; C-REACTIVE PROTEIN; TROPHOBLAST CELLS; GROWTH-FACTOR; DOGS; COAGULATION; ABNORMALITIES; ANGIOGENESIS; PROGRESSION; CARCINOMA;

D O I：

10.1111/vco.12089

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Tissue factor (TF) expression in human cancers has been associated with a procoagulant state and facilitation of metastasis. This study was conducted in order to evaluate if TF was expressed in canine mammary tumours. Forty epithelial mammary tumours from 28 dogs were included. TF expression of the tumours was evaluated by immunohistochemistry using a polyclonal antibody against recombinant canine TF. In addition, thromboelastography, haemostatic and inflammatory parameters were evaluated in the patients. TF was recognized in 44% of benign and 58% of malignant tumours. TF localized to the cytoplasmic membrane of neoplastic luminal epithelial cells and/or diffusely in the cytoplasm. No association was found between TF expression and stage or grade of disease. A significant association between TF expression and antithrombin and plasminogen was found, and extensive TF expression was seen in a lymph node metastasis classified as anaplastic mammary carcinoma from a dog with concomitant disseminated intravascular coagulation (DIC).

引用

页码：191 / 201

页数：11

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