Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease

被引：28

作者：

Wilke, Carlo ^{[1
,2
]}

Gillardon, Frank ^{[3
]}

Deuschle, Christian ^{[1
,2
]}

Dubois, Evelyn ^{[1
,2
]}

Hobert, Markus A. ^{[1
,2
]}

vom Hagen, Jennifer Mueller ^{[1
,2
]}

Krueger, Stefanie ^{[4
]}

Biskup, Saskia ^{[4
]}

Blauwendraat, Cornelis ^{[5
]}

Hruscha, Michael ^{[5
]}

Kaeser, Stephan A. ^{[6
,7
]}

Heutink, Peter ^{[5
]}

Maetzler, Walter ^{[1
,2
]}

Synofzik, Matthis ^{[1
,2
]}

机构：

[1] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, Hoppe Seyler Str 3, D-72076 Tubingen, Germany

[2] Univ Tubingen, Hertie Inst Clin Brain Res, German Ctr Neurodegenerat Dis, D-72076 Tubingen, Germany

[3] Boehringer Ingelheim Pharma GmbH & Co KG, CNS Dis Res, Biberach, Germany

[4] CeGaT GmbH, Ctr Genom & Transcript, Tubingen, Germany

[5] Univ Tubingen, Ctr Neurodegenerat Dis, Genome Biol Neurodegenerat Dis, D-72076 Tubingen, Germany

[6] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Cellular Neurol, D-72076 Tubingen, Germany

[7] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

来源：

CURRENT ALZHEIMER RESEARCH | 2016年 / 13卷 / 06期

关键词：

Alzheimer's dementia; amyotrophic lateral sclerosis; biomarker; case-control study; cerebrospinal fluid; frontotemporal dementia; GRN; progranulin; serum; ALZHEIMERS-DISEASE; PLASMA; MUTATIONS; EXPRESSION; DIAGNOSIS; FRAMEWORK; CRITERIA;

D O I：

10.2174/1567205013666160314151247

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on progranulin regulation in neurodegenerative diseases remains limited. We here demonstrate that cerebrospinal fluid progranulin levels do not correlate with its serum levels in AD, FTD and ALS, indicating a differential regulation of its central and peripheral levels in neurodegeneration. Blood progranulin levels thus do not reliably predict central nervous progranulin levels and their response to future progranulin-increasing therapeutics.

引用

页码：654 / 662

页数：9

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