Insights Into Host Cell Cytokines in Chlamydia Infection

被引：33

作者：

Xiang, Wenjing ^{[1
]}

Yu, Nanyan ^{[1
]}

Lei, Aihua ^{[1
]}

Li, Xiaofang ^{[1
]}

Tan, Shui ^{[1
]}

Huang, Lijun ^{[1
,2
,3
]}

Zhou, Zhou ^{[1
]}

机构：

[1] Univ South China, Inst Pathogen Biol, Hengyang Med Coll,Hunan Prov Cooperat Innovat Ctr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang, Peoples R China

[2] Univ South China, Nanyue Biopharmaceut Co Ltd, Hunan Prov Innovat Training Base Postgrad, Hengyang, Peoples R China

[3] Nanyue Biopharmaceut Co Ltd, Hengyang, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

湖南省自然科学基金; 中国国家自然科学基金;

关键词：

Chlamydia; infection; cytokines; inflammation; pathology; PROINFLAMMATORY CYTOKINES; PNEUMONIAE INFECTION; IMMUNE-RESPONSES; TRACHOMATIS; EXPRESSION; FAMILY; INTERLEUKIN-6; INFLAMMATION; CLEARANCE; SECRETION;

D O I：

10.3389/fimmu.2021.639834

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chlamydial infection causes a number of clinically relevant diseases and induces significant morbidity in humans. Immune and inflammatory responses contribute to both the clearance of Chlamydia infection and pathology in host tissues. Chlamydia infection stimulates host cells to produce a large number of cytokines that trigger and regulate host immune responses against Chlamydia. However, inappropriate responses can occur with excessive production of cytokines, resulting in overreactive inflammatory responses and alterations in host or Chlamydia metabolism. As a result, Chlamydia persists and causes wound healing delays, leading to more severe tissue damage and triggering long-lasting fibrotic sequelae. Here, we summarize the roles of cytokines in Chlamydia infection and pathogenesis, thus advancing our understanding chlamydial infection biology and the pathogenic mechanisms involved.

引用

页数：14

共 174 条

[1]

Abu el-Asrar A M, 2001, Bull Soc Belge Ophtalmol, P73

[2] Immunopathogenesis of conjunctival scarring in trachoma [J].