Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia

被引：38

作者：

Wang, S

Degar, BA

Zieske, A

Shafi, NQ

Rose, MG

机构：

[1] VA Connecticut Healthcare Syst, IIID, Ctr Canc, West Haven, CT 06516 USA

[2] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

[3] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06510 USA

[4] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[5] Childrens Hosp, Boston, MA 02115 USA

[6] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA

[7] Vet Adm Connecticut Healthcare Syst, Dept Med, West Haven, CT USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2004年 / 77卷 / 04期

关键词：

hemophagocytosis; thrombophagocytosis; G-CSF; GM-CSF; myelodysplasia; splenectomy;

D O I：

10.1002/ajh.20202

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a 75-year-old man with neutropenia in whom bone marrow aspirate and biopsy demonstrated hemophagocytosis associated with myelodysplasia (MDS). Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which recurred upon rechallenge. We propose that myeloid growth factors may be detrimental in patients with MDS-associated hemophagocytosis. (C) 2004 Wiley-Liss, Inc.

引用

页码：391 / 396

页数：6

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