The induction of apoptosis by local anesthetics: A comparison between lidocaine and ropivacaine

被引:54
作者
Boselli, E
Duflo, F
Debon, R
Allaouchiche, B
Chassard, D [1 ]
Thomas, L
Portoukalian, J
机构
[1] Hop Hotel Dieu, Serv Anesthesie Reanimat, Dept Anesthesiol & Intens Care, F-69002 Lyon, France
[2] Ctr Hosp Lyon Sud, INSERM, Unite 346, Lab Glycobiol, F-69310 Pierre Benite, France
关键词
D O I
10.1213/01.ANE.0000047201.85815.9D
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
This study suggests that lidocaine can induce apoptosis (detected by dual staining with Annexin V and propidium iodide) on T-cell line cultures in a time-dependent manner. This was not observed with ropivacaine.
引用
收藏
页码:755 / 756
页数:2
相关论文
共 9 条
[1]   Does chronic occupational exposure to volatile anesthetic agents influence the rate of neutrophil apoptosis? [J].
Goto, Y ;
Gallagher, J ;
Fanning, N ;
Wang, JH ;
McCusker, S ;
Redmond, P ;
Shorten, G .
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 2000, 47 (04) :350-353
[2]   Potential neurotoxicity of spinal anesthesia with lidocaine [J].
Johnson, ME .
MAYO CLINIC PROCEEDINGS, 2000, 75 (09) :921-932
[3]  
JOHNSON ME, 2001, ANESTHESIOLOGY S, V95, pA985
[4]  
NASSOGNE MC, 1998, ANN NY ACAD SCI, V846, P54
[5]   Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics [J].
Sztark, F ;
Malgat, M ;
Dabadie, P ;
Mazat, JP .
ANESTHESIOLOGY, 1998, 88 (05) :1340-1349
[6]   Effects of chronic occupational exposure to anaesthetic gases on the rate of neutrophil apoptosis among anaesthetists [J].
Tyther, R ;
Halligan, M ;
Wang, J ;
Redmond, HP ;
Shorten, G .
EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2002, 19 (08) :604-608
[7]   The effect of the anaesthetic agent isoflurane on the rate of neutrophil apoptosis in vitro [J].
Tyther, R ;
Fanning, N ;
Halligan, M ;
Wang, J ;
Redmond, HP ;
Shorten, G .
IRISH JOURNAL OF MEDICAL SCIENCE, 2001, 170 (01) :41-44
[8]   A NOVEL ASSAY FOR APOPTOSIS - FLOW CYTOMETRIC DETECTION OF PHOSPHATIDYLSERINE EXPRESSION ON EARLY APOPTOTIC CELLS USING FLUORESCEIN-LABELED ANNEXIN-V [J].
VERMES, I ;
HAANEN, C ;
STEFFENSNAKKEN, H ;
REUTELINGSPERGER, C .
JOURNAL OF IMMUNOLOGICAL METHODS, 1995, 184 (01) :39-51
[9]  
Weinberg G, 1998, ANESTHESIOLOGY, V89, pU1065