N-allylation of anilides with chiral palladium catalysts:: the first catalytic asymmetric synthesis of axially chiral anilides

被引：107

作者：

Terauchi, J ^{[1
]}

Curran, DP ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 05期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0957-4166(03)00041-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The first catalytic asymmetric synthesis of axially chiral anilides has been carried out under palladium-catalyzed allylation reaction conditions with chiral phosphine ligands. Allylation of anilides bearing an ortho tert-butyl group with a palladium catalyst and (S)-BINAP as a chiral ligand gave axially chiral anilides in about 50% ee. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：587 / 592

页数：6