N-allylation of anilides with chiral palladium catalysts:: the first catalytic asymmetric synthesis of axially chiral anilides

被引：107
作者：
Terauchi, J [1 ]
Curran, DP [1 ]
机构：
[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA
来源：
TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 05期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/S0957-4166(03)00041-7
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The first catalytic asymmetric synthesis of axially chiral anilides has been carried out under palladium-catalyzed allylation reaction conditions with chiral phosphine ligands. Allylation of anilides bearing an ortho tert-butyl group with a palladium catalyst and (S)-BINAP as a chiral ligand gave axially chiral anilides in about 50% ee. (C) 2003 Elsevier Science Ltd. All rights reserved.
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页码：587 / 592
页数：6
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