KOtBu-BF3.OEt2 mediated synthesis of quinazolin-4(3H)-ones from 2-substituted amides with nitriles and aldehydes

被引：4

作者：

Nomula, Vishnuvardhan ^{[1
,2
]}

Rao, Sadu Nageswara ^{[1
,3
]}

机构：

[1] CSIR Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, Hyderabad, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad, India

[3] Sci & Engn Res Board Natl Post Doctoral Fellowshi, Hyderabad, India

来源：

SYNTHETIC COMMUNICATIONS | 2021年 / 51卷 / 17期

关键词：

Nitriles; aldehydes; KOtBu; quinazolinones; metal-free conditions; ONE-POT SYNTHESIS; C-H AMIDATION; QUINAZOLINE DERIVATIVES; FUSED QUINAZOLINONES; 2,3-DISUBSTITUTED QUINAZOLIN-4(3H)-ONES; CARBONYLATIVE SYNTHESIS; OXIDATIVE SYNTHESIS; CATALYZED SYNTHESIS; O-AMINOBENZAMIDES; DOMINO SYNTHESIS;

D O I：

10.1080/00397911.2021.1928218

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(KOBu)-Bu-t-BF3.OEt2 mediated synthesis of quinazolin-4(3H)-ones from 2-substituted amides with nitriles and aldehydes have been developed. In this protocol, a variety of nitriles as well as aldehydes react with 2-substituted benzamides to corresponding quinazolin-4(3H)-ones products in good to moderate yields, via the cleavage of C-X and C-N bonds and the formation of double C-N bonds simultaneously, in presence of potassium tert-butoxide.

引用

页码：2602 / 2612

页数：11

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