A peptide hydrogel derived from a fragment of human cardiac troponin C

被引：16

作者：

De Leon-Rodriguez, Luis M. ^{[1
]}

Kamalov, Meder ^{[2
]}

Hemar, Yacine ^{[2
]}

Mitra, Alok K. ^{[1
]}

Castelletto, Valeria ^{[3
]}

Hermida-Merino, Daniel ^{[4
]}

Hamley, Ian W. ^{[3
]}

Brimble, Margaret A. ^{[1
]}

机构：

[1] Univ Auckland, Sch Biol Sci, 3 Symonds St, Auckland 1, New Zealand

[2] Univ Auckland, Sch Chem Sci, 3 Symonds St, Auckland 1, New Zealand

[3] Univ Reading, Sch Chem Food Sci & Pharm, Reading RG6 6AF, Berks, England

[4] European Synchrotron Radiat Lab ESRF, Grenoble, France

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 21期

基金：

英国工程与自然科学研究理事会;

关键词：

DESIGNED PEPTIDE; AMYLOID FIBRILS; FIBRILLIZATION; MECHANISM; MODEL;

D O I：

10.1039/c6cc00209a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The human cardiac troponin C peptide fragment H-V(9)EQLTEEQKN EFKAAFDIFVLGA(31)-OH, which covers helix-A in the native protein, self-assembles into b-sheet fibrils in solution. These fibrils further entangle to give a hydrogel. This peptide may therefore serve as a template for development of novel biomaterials.

引用

页码：4056 / 4059

页数：4

共 32 条

[1] Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes [J].

Aggeli, A ;

Bell, M ;

Boden, N ;

Keen, JN ;

Knowles, PF ;

McLeish, TCB ;

Pitkeathly, M ;

Radford, SE .

NATURE, 1997, 386 (6622) :259-262

[2] Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases [J].

Bucciantini, M ;

Giannoni, E ;

Chiti, F ;

Baroni, F ;

Formigli, L ;

Zurdo, JS ;

Taddei, N ;

Ramponi, G ;

Dobson, CM ;

Stefani, M .

NATURE, 2002, 416 (6880) :507-511

[3] Hydrogelation of self-assembling RGD-based peptides [J].

Cheng, G. ;

Castelletto, V. ;

Jones, R. R. ;

Connon, C. J. ;

Hamley, I. W. .

SOFT MATTER, 2011, 7 (04) :1326-1333

[4] Protein misfolding, functional amyloid, and human disease [J].

Chiti, Fabrizio ;

Dobson, Christopher M. .

ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 :333-366

[5] Enzymatic modification of self-assembled peptide structures with tissue transglutaminase [J].

Collier, JH ;

Messersmith, PB .

BIOCONJUGATE CHEMISTRY, 2003, 14 (04) :748-755

[6] Modular self-assembling biomaterials for directing cellular responses [J].

Collier, Joel H. .

SOFT MATTER, 2008, 4 (12) :2310-2315

[7] Molecular Structure of RADA16-I Designer Self-Assembling Peptide Nanofibers [J].

Cormier, Ashley R. ;

Pang, Xiaodong ;

Zimmerman, Maxwell I. ;

Zhou, Huan-Xiang ;

Paravastu, Anant K. .

ACS NANO, 2013, 7 (09) :7562-7572

[8]

Filatov VL, 1999, BIOCHEMISTRY-MOSCOW+, V64, P969

[9] A pH-responsive coiled-coil peptide hydrogel [J].

Fletcher, Nicholas L. ;

Lockett, Christina V. ;

Dexter, Annette F. .

SOFT MATTER, 2011, 7 (21) :10210-10218

[10] A peptide from human semenogelin I self-assembles into a pH-responsive hydrogel [J].

Frohm, B. ;

DeNizio, J. E. ;

Lee, D. S. M. ;

Gentile, L. ;

Olsson, U. ;

Malm, J. ;

Akerfeldt, K. S. ;

Linse, S. .

SOFT MATTER, 2015, 11 (02) :414-421

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