The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin

被引：139

作者：

Tucci, SA

Rogers, EK

Korbonits, M

Kirkham, TC

机构：

[1] Univ Liverpool, Sch Psychol, Liverpool L69 7ZA, Merseyside, England

[2] St Bartholomews Hosp, Dept Endocrinol, London EC1A 7BE, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2004年 / 143卷 / 05期

关键词：

ghrelin; endocannabinoid; PVN; appetite; SR141716;

D O I：

10.1038/sj.bjp.0705968

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The paraventricular nucleus (PVN) of the hypothalamus plays a key role in the control of appetite and energy balance. Both ghrelin and cannabinoid receptor agonists increase food intake when administered into this nucleus: this study investigated possible interactions between the two systems in relation to eating. The orexigenic effect of ghrelin (100 pmol) when infused in to the PVN was reversed by a small, systemic dose of the CB1 cannabinoid receptor antagonist SR141716 (1 mg kg(-1)). This is the first demonstration of a functional relationship between brain ghrelin and endocannabinoid systems, and, although it needs to be further investigated, the effect of ghrelin on food intake when injected into the PVN seems to be mediated by stimulation of cannabinoid release.

引用

页码：520 / 523

页数：4

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