Inactivation of the medial prefrontal cortex with the GABAA receptor agonist muscimol increases open-arm activity in the elevated plus-maze and attenuates shock-probe burying in rats

被引：81

作者：

Shah, AA ^{[1
]}

Sjovold, T ^{[1
]}

Treit, D ^{[1
]}

机构：

[1] Univ Alberta, Dept Psychol, Edmonton, AB T6G 2E9, Canada

来源：

BRAIN RESEARCH | 2004年 / 1028卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

gamma-aminobutyric-acid; anxiety; fear; infralimbic; prelimbic; intracerebral infusion;

D O I：

10.1016/j.brainres.2004.08.061

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examined the effects of infusions of a direct GABA(A) receptor agonist, muscimol, into the medial prefrontal cortex (MPFC), on fear behavior measured in the elevated plus-maze and shock-probe burying tests. Bilateral infusions of either a 0.175 or 4 nmol/0.5 mul dose of muscimol increased the percentage of entries and time spent in the open arms, and attenuated shock-probe burying. These findings indicate that intra-MPFC infusions of muscimol induce anxiolysis, and suggest that the direct stimulation of MPFC GABA(A) receptors attenuates fearrelated behavior. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：112 / 115

页数：4

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