Decreased levels of fibrinogen in very high parity women

Objectives: To evaluate coagulation parameters in healthy pregnant grand grand multiparous women. Study design: Prothrombin time (PT), activated partial thromboplastin time (PTT), fibrinogen, D-dimer, albumin and blood lipids were prospectively determined in 50 pregnant grand grand multiparas (greater than or equal to9 deliveries) and 50 age-matched pregnant women with low parity (less than or equal to3 deliveries). Results: The average concentrations of fibrinogen in the grand grand multiparas were 4.0 +/- 0.6 as compared to 4.7+/-0.7 g/l in the control group (P < 0.001). In both groups D-dimer levels were >1000 ng/ml and the concentrations of albumin, triglycerides, cholesterol, high-density lipoprotein (HDL) were not significantly different. Conclusions: In healthy pregnant grand grand multiparous women fibrinogen levels are lower than in age-matched women with low parity. These changes are not directly associated with lipids metabolism during pregnancy. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.