Red/Near-Infrared Emissive Metalloporphyrin-Based Nanodots for Magnetic Resonance Imaging-Guided Photodynamic Therapy In Vivo

被引：57

作者：

Wu, Fengshou ^{[1
,2
]}

Chen, Jingwen ^{[3
]}

Li, Zhicong ^{[3
]}

Su, Huifang ^{[4
]}

Leung, Ken Cham-Fai ^{[2
]}

Wang, Han ^{[3
]}

Zhu, Xunjin ^{[2
]}

机构：

[1] Wuhan Inst Technol, Sch Chem Engn & Pharm, Minist Educ, Key Lab Green Chem Proc, Wuhan 430205, Hubei, Peoples R China

[2] Hong Kong Baptist Univ, Dept Chem, Waterloo Rd, Hong Kong 999077, Hong Kong, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Radiol, Shanghai 200080, Peoples R China

[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Osteol, Zhengzhou 450000, Henan, Peoples R China

来源：

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION | 2018年 / 35卷 / 09期

基金：

中国国家自然科学基金;

关键词：

magnetic resonance imaging; nanodots; near-infrared; photodynamic therapy; porphyrin; CARBON QUANTUM DOTS; FACILE SYNTHESIS; FLUORESCENT; PORPHYRIN; PHOTOSENSITIZER; NANOPARTICLES; THERANOSTICS; NANOSHEETS; SULFUR; PROBES;

D O I：

10.1002/ppsc.201800208

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Near-infrared emissive (NIR) porphyrin-implanted carbon nanodots (PCNDs or MPCNDs) are prepared by selectively carbonization of free base or metal complexes [M = Zn(II) or Mn(III)] of tetra-(meso-aminophenyl)porphyrin in the presence of citric acid. The as-prepared nanodots exhibit spontaneously NIR emission, small size, good aqueous dispersibility, and favorable biocompatibility characteristic of both porphyrins and pristine carbon nanodots. The subcellular localization experiment of nanodots indicates a lysosome-targeting feature. And the in vitro photodynamic therapy (PDT) results on HeLa cells indicate the nanodots alone have no adverse effect on tumor cells, but display remarkable photodynamic efficacy upon irradiation. Moreover, MnPCNDs containing paramagnetic Mn(III) ions, which possesses good biocompatibility, NIR luminescence, and magnetic resonance imaging and efficient singlet oxygen production, are further studied in magnetic resonance imaging-guided photodynamic therapy in vivo.

引用

页数：7

共 43 条

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