Long-term survival of dogs with stage 4 oral malignant melanoma treated with anti-canine PD-1 therapeutic antibody: A follow-up case report

被引:22
作者
Igase, Masaya [1 ]
Inanaga, Sakuya [1 ]
Tani, Kenji [2 ]
Nakaichi, Munekazu [3 ]
Sakai, Yusuke [4 ]
Sakurai, Masashi [4 ]
Kato, Masahiro [5 ]
Tsukui, Toshihiro [5 ]
Mizuno, Takuya [1 ]
机构
[1] Yamaguchi Univ, United Grad Sch Vet Med, Lab Mol Diagnost & Therapeut, Yamaguchi 7538515, Japan
[2] Yamaguchi Univ, Joint Fac Vet Med, Lab Vet Surg, Yamaguchi, Japan
[3] Yamaguchi Univ, Joint Fac Vet Med, Lab Vet Radiol, Yamaguchi, Japan
[4] Yamaguchi Univ, Joint Fac Vet Med, Lab Vet Pathol, Yamaguchi, Japan
[5] Nippon Zenyaku Kogyo Co Ltd, Koriyama, Fukushima, Japan
关键词
cancer; canine; immunotherapy; monoclonal antibody; programmed cell death 1 receptor; IMMUNE-RELATED RESPONSE; CANCER;
D O I
10.1111/vco.12829
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
A monoclonal antibody targeting programmed cell death-1 (PD-1) is one of the most promising treatments for human cancers. Clinical studies in humans demonstrated that the anti-PD-1 antibody provides a long-lasting tumour response. Previously, we established an anti-canine PD-1 therapeutic antibody (ca-4F12-E6), and the pilot clinical study demonstrated that the antibody was effective in dogs with oral malignant melanoma (OMM). However, two OMM cases were still undergoing treatment when the pilot study was published. Here, we describe the long-term follow-up of those two cases. Although both cases showed long-term survival with complete response (CR), the tumour response differed; the effect onset was slow in one case and a durable response was observed in the second case even after treatment discontinuation. Secondary malignant tumours occurred during treatment in both cases. This follow-up study revealed that ca-4F12-E6 maintains CR in dogs for more than 1 year. In addition, the pattern of tumour response was unique compared to conventional therapy. These results indicate that new evaluation criteria for tumour response may be necessary for immunotherapy in veterinary medicine. Long-term follow-up is necessary regardless of the short-term treatment responsiveness.
引用
收藏
页码:901 / 905
页数:5
相关论文
共 31 条
[1]   Pseudoprogression and Immune-Related Response in Solid Tumors [J].
Chiou, Victoria L. ;
Burotto, Mauricio .
JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (31) :3541-+
[2]   Clinical Challenges of Immune Checkpoint Inhibitors [J].
de Miguel, Maria ;
Calvo, Emiliano .
CANCER CELL, 2020, 38 (03) :326-333
[3]   Radiologic Heterogeneity in Responses to Anti-PD-1/PD-L1 Therapy in Metastatic Renal Cell Carcinoma [J].
de Velasco, Guillermo ;
Krajewski, Katherine M. ;
Albiges, Laurence ;
Awad, Mark M. ;
Bellmunt, Joaquim ;
Hodi, F. Stephen ;
Choueiri, Toni K. .
CANCER IMMUNOLOGY RESEARCH, 2016, 4 (01) :12-17
[4]   Different responses to anti-programmed cell death protein 1 (PD-1) immunotherapy in a patient with Lynch syndrome and metachronous urothelial and colon cancer: A case report [J].
Feng, Yu ;
Cao, Yufeng ;
Yuan, Mingming ;
Chen, Rongrong ;
Ji, Xue ;
Hu, Xingsheng .
ONCOLOGY LETTERS, 2019, 18 (05) :5085-5090
[5]   Combination of cytokine-enhanced vaccine and chemo-gene therapy as surgery adjuvant treatments for spontaneous canine melanoma [J].
Finocchiaro, Liliana M. E. ;
Agnetti, Lucrecia ;
Fondello, Chiara ;
Glikin, Gerardo C. .
GENE THERAPY, 2019, 26 (10-11) :418-431
[6]   Long-Term Survival in Patients Responding to Anti-PD-1/PD-L1 Therapy and Disease Outcome upon Treatment Discontinuation [J].
Gauci, Marie-Lea ;
Lanoy, Emilie ;
Champiat, Stephane ;
Caramella, Caroline ;
Ammari, Samy ;
Aspeslagh, Sandrine ;
Varga, Andrea ;
Baldini, Capucine ;
Bahleda, Rastilav ;
Gazzah, Anas ;
Michot, Jean-Marie ;
Postel-Vinay, Sophie ;
Angevin, Eric ;
Ribrag, Vincent ;
Hollebecque, Antoine ;
Soria, Jean-Charles ;
Robert, Caroline ;
Massard, Christophe ;
Marabelle, Aurelien .
CLINICAL CANCER RESEARCH, 2019, 25 (03) :946-956
[7]   Difference in outcome between curative intent vs marginal excision as a first treatment in dogs with oral malignant melanoma and the impact of adjuvant CSPG4-DNA electrovaccination: A retrospective study on 155 cases [J].
Giacobino, Davide ;
Camerino, Mariateresa ;
Riccardo, Federica ;
Cavallo, Federica ;
Tarone, Lidia ;
Martano, Marina ;
Dentini, Alfredo ;
Iussich, Selina ;
Lardone, Elena ;
Franci, Paolo ;
Valazza, Alberto ;
Manassero, Luca ;
Del Magno, Sara ;
De Maria, Raffaella ;
Morello, Emanuela ;
Buracco, Paolo .
VETERINARY AND COMPARATIVE ONCOLOGY, 2021, 19 (04) :651-660
[8]   Development of Thyroid Carcinoma During Treatment With Pembrolizumab in a Lung Cancer Patient [J].
Gorospe, Luis ;
Garcia-Gomez-Muriel, Isabel ;
Pian-Arias, Hector Gerardo ;
Gomez-Ramirez, Joaquin ;
Rioja-Martin, Maria Eugenia ;
Olmedo-Garcia, Maria Eugenia ;
Garrido-Lopez, Pilar ;
Munoz-Molina, Gemma Maria ;
Mezquita, Laura .
ANNALS OF THORACIC SURGERY, 2020, 109 (06) :E397-E399
[9]   Immune checkpoint inhibitor treatment of a first cancer is associated with a decreased incidence of second primary cancer [J].
Heudel, P. ;
Chabaud, S. ;
Perol, D. ;
Flechon, A. ;
Fayette, J. ;
Combemale, P. ;
Tredan, O. ;
Desseigne, F. ;
de la Fouchardiere, C. ;
Boyle, H. ;
Perol, M. ;
Bachelot, T. ;
Cassier, P. ;
Avrillon, V ;
Terret, C. ;
Michallet, A-S ;
Neidhardt-Berard, E-M ;
Nicolas-Virelizier, E. ;
Dufresne, A. ;
Belhabri, A. ;
Brahmi, M. ;
Lebras, L. ;
Nicolini, F. ;
Sarabi, M. ;
Rey, P. ;
Bonneville-Levard, A. ;
Rochefort, P. ;
Provensal, A-M ;
Eberst, L. ;
Assaad, S. ;
Swalduz, A. ;
Saintigny, P. ;
Toussaint, P. ;
Guillermin, Y. ;
Castets, M. ;
Coutzac, C. ;
Meeus, P. ;
Dupre, A. ;
Durand, T. ;
Crochet, H. ;
Fervers, B. ;
Gomez, F. ;
Rivoire, M. ;
Gregoire, V ;
Claude, L. ;
Chassagne-Clement, C. ;
Pilleul, F. ;
Mognetti, T. ;
Russias, B. ;
Soubirou, J-L .
ESMO OPEN, 2021, 6 (01)
[10]   Evaluation of Immune-Related Response Criteria and RECIST v1.1 in Patients With Advanced Melanoma Treated With Pembrolizumab [J].
Hodi, F. Stephen ;
Hwu, Wen-Jen ;
Kefford, Richard ;
Weber, Jeffrey S. ;
Daud, Adil ;
Hamid, Omid ;
Patnaik, Amita ;
Ribas, Antoni ;
Robert, Caroline ;
Gangadhar, Tara C. ;
Joshua, Anthony M. ;
Hersey, Peter ;
Dronca, Roxana ;
Joseph, Richard ;
Hille, Darcy ;
Xue, Dahai ;
Li, Xiaoyun Nicole ;
Kang, S. Peter ;
Ebbinghaus, Scot ;
Perrone, Andrea ;
Wolchok, Jedd D. .
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (13) :1510-+