RUNX1 promotes MAPK signaling to increase tumor progression and metastasis via OPN in head and neck cancer

被引：22

作者：

Liu, Kai ^{[1
,2
]}

Hu, Huiying ^{[1
,2
]}

Jiang, Huanyu ^{[1
,2
]}

Zhang, Haidong ^{[2
]}

Gong, Shanchun ^{[2
]}

Wei, Dongmin ^{[3
]}

Yu, Zhenkun ^{[1
,2
]}

机构：

[1] Southeast Univ, Sch Med, 87 Dingjiaqiao,Hunan Rd, Nanjing 210009, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Dept Otolaryngol Head & Neck Surg, Affiliated BenQ Hosp, Nanjing, Jiangsu, Peoples R China

[3] Shandong Univ, NHC Key Lab Otorhinolaryngol, Dept Otorhinolaryngol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China

来源：

CARCINOGENESIS | 2021年 / 42卷 / 03期

关键词：

SQUAMOUS-CELL CARCINOMA; TRANSCRIPTION FACTOR; GASTRIC-CANCER; OSTEOPONTIN; PATHWAY; EXPRESSION; ANGIOGENESIS; ACTIVATION; SIGNATURE; MIGRATION;

D O I：

10.1093/carcin/bgaa116

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thmor progression and metastasis are still major burdens for head and neck squamous cell carcinoma (HNSCC). Runtrelated transcription factor 1 (RUNX1) is involved in aggressive phenotypes in several cancers, while the molecular role of RUNX1 underlying cancer progression and metastasis of HNSCC remains largely unknown. In our study, RUNX1 expression was increased with disease progression in patients with HNSCC. The silencing of RUNX1 significantly decelerated the malignant progression of HNSCC cells, reduced osteopontin (OPN) expression in vitro and weakened the tumorigenicity of HNSCC cells in vivo. Moreover, we demonstrated that RUNX1 activated the mitogen-activated protein kinase signaling by directly binding to the promoter of OPN in tumor progression and metastasis of HNSCC. Our results may provide new insight into the mechanisms underlying the role of RUNX1 in tumor progression and metastasis and reveal the potential therapeutic target in HNSCC.

引用

页码：414 / 422

页数：9