Lignans from the seeds of Chinese hawthorn (Crataegus pinnatifida var. major NEBr.) against -amyloid aggregation

被引：21

作者：

Huang, Xiao-Xiao ^{[1
,2
]}

Xu, Yang ^{[1
]}

Bai, Ming ^{[1
]}

Zhou, Le ^{[1
]}

Song, Shao-Jiang ^{[1
]}

Wang, Xiao-Bo ^{[2
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang, Liaoning, Peoples R China

[2] Chinese Peoples Liberat Army 210 Hosp, Dalian, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 14期

关键词：

Hawthorn; lignans; Alzheimer's disease; A inhibition; molecular docking; ALZHEIMERS-DISEASE; BETA AGGREGATION; DERIVATIVES; INHIBITION; ACID;

D O I：

10.1080/14786419.2017.1399378

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical investigation on the seeds of hawthorn (Crataegus spp.) led to the isolation of a new compound, (7R, 8R, 8S)-isolariciresinol (1), along with six known compounds (2-7). The structures of all compounds were determined based on spectroscopic data interpretation. The A(1-42) inhibition activity of all isolated compounds was evaluated in vitro. As a result, compounds 5 and 6 showed stronger inhibition of A(1-42) aggregation than curcumin, with inhibition rates of 70.59 and 68.14% at 20M. The possible mechanism of interaction between A(1-42) and the active compounds 5 and 6 was also investigated by molecular docking. [GRAPHICS] .

引用

页码：1706 / 1713

页数：8

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