Coumarins from Angelica dahurica and Their Antitumor Activities in Human MG-63 Osteosarcoma Cells

被引：7

作者：

Chen, Weizhen ^{[1
]}

Wang, Guokai ^{[2
]}

Mei, Ke ^{[3
]}

Zhu, Jianyong ^{[4
]}

机构：

[1] Huangshan Vocat & Tech Coll, Dept Med, Huangshan 245000, Anhui, Peoples R China

[2] Anhui Univ Chinese Med, Sch Pharm, Anhui Prov Key Lab Res & Dev Chinese Med, Hefei 230012, Anhui, Peoples R China

[3] Dahua Hosp Xuhui Dist, Shanghai 200237, Peoples R China

[4] Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Shanghai 200137, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2021年 / 15卷 / 05期

关键词：

Angelica dahurica; coumarin; apoptosis; cytotoxicity; BARK;

D O I：

10.25135/rnp.225.21.01.1935

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new coumarin, angedahurin A (1), and seven known analogues (2-8), were isolated from the roots of Angelica dahurica. Their structures were identified by extensive NMR, IR, and HR-ESIMS spectroscopic analyses. The cytotoxicities of coumarins 1-8 against MG-63 human osteosarcoma cell lines were screened. Compound 1 showed significant cytotoxic effects against MG-63 with an IC50 value of 7.2.M,for comparison, the positive control, 5-FU, had an IC50 value of 32.4. M. Morphological features of apoptosis activities were evaluated in 1-induced MG-63 cells and the results confirmed MG-63 cell apoptosis in a dose-dependent manner.

引用

页码：356 / 362

页数：7

共 15 条

[1] A VERSATILE ROUTE FOR THE SYNTHESIS OF 3-(1',1'-DIMETHYLALLYL)COUMARINS
AHLUWALIA, VK
SINGH, RP
BALA, S
[J]. TETRAHEDRON LETTERS, 1982, 23 (19) : 2049 - 2050
[2] Oleodaphnoic Acid and Coriaceol, Two New Natural Products from the Stem Bark of Wikstroemia coriacea
Ingert, Nicolas
Bombarda, Isabelle
Herbette, Gaetan
Faure, Robert
Moretti, Christian
Raharivelomanana, Phila
[J]. MOLECULES, 2013, 18 (03): : 2988 - 2996
[3] HIGHLY OXYGENATED COUMARINS FROM PELARGONIUM SIDOIDES
KAYSER, O
KOLODZIEJ, H
[J]. PHYTOCHEMISTRY, 1995, 39 (05) : 1181 - 1185
[4] Benzofuran and coumarin derivatives from the root of Angelica dahurica and their PPAR-γ ligand-binding activity
Matsuo, Yukiko
Yamaguchi, Emi
Hakamata, Ryo
Ootomo, Kanae
Takatori, Kazuhiro
Fukaya, Haruhiko
Mimaki, Yoshihiro
[J]. PHYTOCHEMISTRY, 2020, 173
[5] Chemical Composition of Hexane Extract of Citrus aurantifolia and Anti-Mycobacterium tuberculosis Activity of Some of Its Constituents
Sandoval-Montemayor, Nallely E.
Garcia, Abraham
Elizondo-Trevino, Elizabeth
Garza-Gonzalez, Elvira
Alvarez, Laura
del Rayo Camacho-Corona, Maria
[J]. MOLECULES, 2012, 17 (09): : 11173 - 11184
[6] Chemical and pharmacological research of the plants in genus Euphorbia
Shi, Qing-Wen
Su, Xiao-Hui
Kiyota, Hiromasa
[J]. CHEMICAL REVIEWS, 2008, 108 (10) : 4295 - 4327
[7] A risk signature-based on metastasis-associated genes to predict survival of patients with osteosarcoma
Shi, Yi
He, Ronghan
Zhuang, Ze
Ren, Jianhua
Wang, Zhe
Liu, Yuangao
Wu, Jiajun
Jiang, Shihai
Wang, Kun
[J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2020, 121 (07) : 3479 - 3490
[8] Isolation, structure elucidation, tyrosinase inhibitory, and antioxidant evaluation of the constituents from Angelica dahurica roots
Shu, Penghua
Li, Junping
Fei, Yingying
Zhu, Huiqing
Yu, Mengzhu
Liu, Anqi
Niu, Haoying
Zou, Simin
Wei, Xialan
Ju, Zhiyu
Xu, Zhihong
[J]. JOURNAL OF NATURAL MEDICINES, 2020, 74 (02) : 456 - 462
[9] TSUKAMOTO H, 1985, CHEM PHARM BULL, V33, P396
[10] Two new ceramides from the fruit pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms
Yan, Zhaowei
Liu, Jinping
Lu, Dan
Narlawar, Rajeshwar
Groundwater, Paul
Li, Pingya
[J]. NATURAL PRODUCT RESEARCH, 2014, 28 (03) : 144 - 149

← 1 2 →