Coumarins from Angelica dahurica and Their Antitumor Activities in Human MG-63 Osteosarcoma Cells

被引：8

作者：

Chen, Weizhen ^{[1
]}

Wang, Guokai ^{[2
]}

Mei, Ke ^{[3
]}

Zhu, Jianyong ^{[4
]}

机构：

[1] Huangshan Vocat & Tech Coll, Dept Med, Huangshan 245000, Anhui, Peoples R China

[2] Anhui Univ Chinese Med, Sch Pharm, Anhui Prov Key Lab Res & Dev Chinese Med, Hefei 230012, Anhui, Peoples R China

[3] Dahua Hosp Xuhui Dist, Shanghai 200237, Peoples R China

[4] Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Shanghai 200137, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2021年 / 15卷 / 05期

关键词：

Angelica dahurica; coumarin; apoptosis; cytotoxicity; BARK;

D O I：

10.25135/rnp.225.21.01.1935

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new coumarin, angedahurin A (1), and seven known analogues (2-8), were isolated from the roots of Angelica dahurica. Their structures were identified by extensive NMR, IR, and HR-ESIMS spectroscopic analyses. The cytotoxicities of coumarins 1-8 against MG-63 human osteosarcoma cell lines were screened. Compound 1 showed significant cytotoxic effects against MG-63 with an IC50 value of 7.2.M,for comparison, the positive control, 5-FU, had an IC50 value of 32.4. M. Morphological features of apoptosis activities were evaluated in 1-induced MG-63 cells and the results confirmed MG-63 cell apoptosis in a dose-dependent manner.

引用

页码：356 / 362

页数：7

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