Highly Selective Ylide-Initiated Michael Addition/Cyclization Reaction for Synthesis of Cyclohexadiene Epoxide and Vinylcyclopropane Derivatives

被引：52

作者：

Zhu, Ben-Hu ^{[1
]}

Zhou, Rui ^{[1
]}

Zheng, Jun-Cheng ^{[2
]}

Deng, Xian-Ming ^{[2
]}

Sun, Xiu-Li ^{[2
]}

Shen, Qi ^{[1
]}

Tang, Yong ^{[2
]}

机构：

[1] Suzhou Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth, Suzhou 215123, Jiangsu Prov, Peoples R China

[2] Shanghai Inst Organ Chem, Dept State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 10期

基金：

中国国家自然科学基金;

关键词：

NEUTRAL SPHINGOMYELINASE INHIBITOR; FRIEDEL-CRAFTS REACTION; ENANTIOSELECTIVE SYNTHESIS; ALPHA; BETA-UNSATURATED ESTERS; BIOLOGICAL-ACTIVITIES; ALDOL ADDITIONS; CYCLOPROPANATION; REVERSAL; CYCLOADDITION; EFFICIENT;

D O I：

10.1021/jo100306z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

On the basis of the reactions of camphor-derived sulfur ylide with alpha,beta-unsaturated ketone, highly efficient and selective synthesis of optically active cyclohexadiene epoxides and vinylcyclopropanes with excellent diastereoselectivities, moderate to high enantioselectivities, and yields has been achieved.

引用

页码：3454 / 3457

页数：4

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