Efficient synthesis of β- and γ-amino acid derivatives using new functionalised zinc reagents:: enhanced stability and reactivity of β-amido zinc reagents in dimethylformamide

被引：30

作者：

Dexter, CS ^{[1
]}

Jackson, RFW ^{[1
]}

机构：

[1] Univ Newcastle Upon Tyne, Dept Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 01期

关键词：

D O I：

10.1039/a707062d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The new zinc reagents 3 and 4 are not sufficiently stable to be prepared efficiently in THF, but they can be prepared in DMF under mild and convenient conditions; subsequent palladium-catalysed coupling with aromatic iodides gives protected beta- and gamma-amino acids 11 and 12 in generally good yields.

引用

页码：75 / 76

页数：2

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