Efficient synthesis of (5-oxo-6,7-dihydro-4H-[1,2,4]triazolo-[1,5-a]pyrimidin-6-yl)acetanilides based on the recyclization of N-arylitaconimides with 3-amino[1,2,4]triazoles

被引：7

作者：

Kovygin, Yu A. ^{[1
]}

Vandyshev, D. Yu ^{[1
]}

Ledenyova, I., V ^{[1
]}

Kosheleva, E. A. ^{[1
]}

Polikarchuk, V. A. ^{[1
]}

Kozaderov, O. A. ^{[1
]}

Shikhaliev, Kh S. ^{[1
]}

机构：

[1] Voronezh State Univ, 1 Univ Skaya Pl, Voronezh 394018, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2021年 / 70卷 / 03期

基金：

俄罗斯科学基金会;

关键词：

triazolopyrimidines; itaconimides; recyclization;

D O I：

10.1007/s11172-021-3118-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient method for the synthesis of 2-(2-R-5-oxo-6,7-dihydro-4H-[1,2,4]triazolo-[1,5-a]pyrimidin-6-yl)acetanilides based on the regioselective domino reaction of N-arylitaconimides with substituted 3-aminotriazoles was proposed. Presumably, the reaction pathway includes the conjugated aza-addition of the endo-nucleophilic center of triazole to imide, followed by the recyclization of the intermediate to triazolo[1,5-a]pyrimidine.

引用

页码：520 / 526

页数：7

共 38 条

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